D-吡喃葡萄糖基肽T衍生物的合成及生物活性
Synthesis and biological activity of D-glucopyranosyl peptide T derivatives.
作者信息
Marastoni M, Spisani S, Tomatis R
机构信息
Department of Pharmaceutical Science, University of Ferrara, Italy.
出版信息
Arzneimittelforschung. 1994 Aug;44(8):984-7.
PMID:7945547
Abstract
The solid phase procedure, based on the Fmoc (9-fluorenylmethyloxycarbonyl) chemistry, was used to prepare some peptide T analogues in which D-glucopyranosyl units are beta-O-glycosidically linked to Thr4 and/or Thr5 side chains. All glycopeptides showed significant human monocyte chemotaxis and high resistance to degradation by plasma or brain enzymes.
摘要
基于Fmoc（9-芴甲氧羰基）化学的固相合成方法被用于制备一些肽T类似物，其中D-吡喃葡萄糖基单元通过β-O-糖苷键连接到苏氨酸4和/或苏氨酸5的侧链上。所有糖肽都表现出显著的人单核细胞趋化性，并且对血浆或脑酶的降解具有高度抗性。
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