Meek Claire L, Lewis Hannah B, Reimann Frank, Gribble Fiona M, Park Adrian J
Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrookes's Hospital, Box 289, Hills Road, Cambridge CB2 0QQ, United Kingdom; Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.
Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Addenbrookes's Hospital, Box 289, Hills Road, Cambridge CB2 0QQ, United Kingdom.
Peptides. 2016 Mar;77:28-37. doi: 10.1016/j.peptides.2015.08.013. Epub 2015 Sep 5.
Bariatric surgery for obesity has proved to be an extremely effective method of promoting long-term weight reduction with additional beneficial metabolic effects, such as improved glucose tolerance and remission of type 2 diabetes. A range of bariatric procedures are in common use, including gastric banding, sleeve gastrectomy and the Roux-en-Y gastric bypass. Although the mechanisms underlying the efficacy of bariatric surgery are unclear, gastrointestinal and pancreatic peptides are thought to play an important role. The aim of this review is to summarise the effects of different bariatric surgery procedures upon gastrointestinal and pancreatic peptides, including ghrelin, gastrin, cholecystokinin (CCK), glucose-dependent insulinotropic hormone (GIP), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), oxyntomodulin, insulin, glucagon and somatostatin.
事实证明,治疗肥胖症的减肥手术是促进长期体重减轻的极其有效的方法,还具有额外的有益代谢作用,如改善葡萄糖耐量和缓解2型糖尿病。一系列减肥手术被广泛应用,包括胃束带术、袖状胃切除术和Roux-en-Y胃旁路术。尽管减肥手术疗效的潜在机制尚不清楚,但胃肠和胰腺肽被认为发挥着重要作用。这篇综述的目的是总结不同减肥手术对胃肠和胰腺肽的影响,包括胃饥饿素、胃泌素、胆囊收缩素(CCK)、葡萄糖依赖性促胰岛素多肽(GIP)、胰高血糖素样肽1(GLP-1)、肽YY(PYY)、胃动素、胰岛素、胰高血糖素和生长抑素。