Division of Translational and Experimental Medicine, Clinical Sciences Research Laboratories, University of Warwick Medical School, Coventry, CV2 2DX, UK.
Academic Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Campus, London, W12 0NN, UK.
Curr Obes Rep. 2017 Sep;6(3):253-265. doi: 10.1007/s13679-017-0276-5.
In recent years, the role of the gastrointestinal (GI) tract in energy homeostasis through modulation of the digestion and absorption of carbohydrates and the production of incretin hormones is well recognized.
Bariatric surgery for obesity has been a very effective method in substantially improving weight, and numerous studies have focused on intestinal adaptation after bariatric procedures. A number of structural and functional changes in the GI tract have been reported postsurgery, which could be responsible for the altered hormonal responses. Furthermore, the change in food absorption rate and the intestinal regions exposed to carbohydrates may affect blood glucose response. This review hopes to give new insights into the direct role of gut hormones, by summarising the metabolic effects of bariatric surgery.
近年来，胃肠道（GI）在通过调节碳水化合物的消化和吸收以及肠促胰岛素激素的产生来维持能量平衡方面的作用得到了充分的认识。
肥胖的减重手术是一种非常有效的方法，可以显著改善体重，并且有许多研究集中在减重手术后肠道的适应性上。手术后报道了 GI 道的许多结构和功能变化，这些变化可能是激素反应改变的原因。此外，食物吸收速度的变化和暴露于碳水化合物的肠道区域可能会影响血糖反应。通过总结减重手术的代谢效应，本综述希望对肠激素的直接作用有新的认识。
