Kennedy Byron S, Weimer Anita C, Bedard Brenden, Nayak Jennifer L, Sacheli Drew, Ricci John, Meyer Donna D, Hubbard Donna
Monroe County Department of Public Health, 111 Westfall Rd., Rochester, NY 14620, USA.
Department of Pediatrics, University of Rochester Medical Center School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14620, USA.
Vaccines (Basel). 2014 Feb 13;2(1):107-11. doi: 10.3390/vaccines2010107.
In late October 2011, the Monroe County Department of Public Health (MCDPH) was notified of a suspected case of meningitis in a 9-year old girl from Monroe County, NY. Laboratory testing at the New York State Department of Health (NYSDOH) Wadsworth Center confirmed the identification of Haemophilus influenzae serotype e (Hie) isolated from the patient's cerebrospinal fluid (CSF) using real-time polymerase chain reaction (RT-PCR). The universal immunization of infants with conjugate H. influenzae type b (Hib) vaccine has significantly reduced the incidence of invasive Hib disease, including meningitis, one of the most serious complications for infected children. Not surprisingly, as the epidemiology of invasive H. influenzae continues to change, non-Hib serotypes will likely become more common. The findings reported here underscore the importance for clinicians, public health officials, and laboratory staff to consider non-Hib pathogens in pediatric cases of meningitis, especially when initial investigations are inconclusive.
2011年10月下旬，门罗县公共卫生部（MCDPH）接到通知，纽约州门罗县一名9岁女孩疑似患脑膜炎。纽约州卫生部（NYSDOH）沃兹沃思中心的实验室检测通过实时聚合酶链反应（RT-PCR），确认从患者脑脊液（CSF）中分离出e型流感嗜血杆菌（Hie）。对婴儿普遍接种b型流感嗜血杆菌结合疫苗（Hib）已显著降低侵袭性Hib疾病的发病率，包括脑膜炎，这是感染儿童最严重的并发症之一。不出所料，随着侵袭性流感嗜血杆菌的流行病学不断变化，非Hib血清型可能会变得更加常见。此处报告的研究结果强调了临床医生、公共卫生官员和实验室工作人员在小儿脑膜炎病例中考虑非Hib病原体的重要性，尤其是在初步调查尚无定论时。
