高度区域选择性、酸催化、三组分级联反应合成 2-氨基吡啶修饰的咪唑并[1,2-a]吡啶。
Highly Regioselective, Acid-Catalyzed, Three-Component Cascade Reaction for the Synthesis of 2-aminopyridine-Decorated Imidazo[1,2- a]pyridine.
机构信息
School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center , Guangdong Pharmaceutical University , Zhongshan 528458 , China.
出版信息
ACS Comb Sci. 2019 Mar 11;21(3):149-153. doi: 10.1021/acscombsci.8b00149. Epub 2019 Jan 22.
PMID:30653293
Abstract
A highly regioselective acid-catalyzed three-component reaction of 2-aminopyridine and 3-phenylpropiolaldehyde for the construction of imidazo[1,2- a]pyridine has been developed. This strategy provides a broad range of substrates and represents an efficient approach to give various 2-aminopyridine-decorated imidazo[1,2- a]pyridine in good yields.
摘要
一种高区域选择性的酸催化三组分反应，由 2-氨基吡啶和 3-苯基丙炔醛构建咪唑并[1,2-a]吡啶，已经被开发出来。该策略提供了广泛的底物范围，并代表了一种有效的方法，可以高产率地得到各种 2-氨基吡啶修饰的咪唑并[1,2-a]吡啶。
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