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2型糖尿病、未诊断糖尿病和糖尿病前期患者的跌倒、身体功能受限、意识模糊及记忆问题,以及维生素A、D和E的影响

Falls, physical limitations, confusion and memory problems in people with type II diabetes, undiagnosed diabetes and prediabetes, and the influence of vitamins A, D and E.

作者信息

Vieira Edgar R, Mendy Angelico, Prado Carla M, Gasana Janvier, Albatineh Ahmed N

机构信息

Departments of Physical Therapy & Neuroscience, Florida International University, Miami, Florida, US.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, US.

出版信息

J Diabetes Complications. 2015 Nov-Dec;29(8):1159-64. doi: 10.1016/j.jdiacomp.2015.08.005. Epub 2015 Aug 10.

DOI:10.1016/j.jdiacomp.2015.08.005
PMID:26344725
Abstract

AIMS

To examine the association between type II diabetes, prediabetes and undiagnosed diabetes with falls, physical limitations, confusion and memory problems, and to evaluate the effects of vitamins A, D and E levels on the associations.

METHODS

Data from 37,973 participants of the National Health and Nutrition Examination Survey was analyzed.

RESULTS

The participants' mean age was 46±17years, 20% had diabetes of which 17% were unaware of their condition (undiagnosed diabetes), and 21% had prediabetes. Diabetes was significantly associated with falls, difficulties in stooping, crouching, kneeling, completing house chores, getting in and out bed, standing and sitting for long periods, reaching over head, grasping, holding objects, and attending social events. The association between diabetes and confusion or memory problems was stronger for those diagnosed before age 40. Memory problems were reported only by people with diabetes with lower vitamin D levels. Vitamin A and E levels did not modify the association between diabetes and falls or any of the physical functions, confusion or memory problems. Prediabetes was only associated with difficulty standing for long periods.

CONCLUSIONS

Diabetes was associated with falls, difficulties in physical functioning and attending social events. Vitamin D levels modified the effects on confusion and memory problems.

摘要

目的

研究2型糖尿病、糖尿病前期及未诊断出的糖尿病与跌倒、身体功能受限、意识模糊和记忆问题之间的关联,并评估维生素A、D和E水平对这些关联的影响。

方法

对来自美国国家健康与营养检查调查的37973名参与者的数据进行了分析。

结果

参与者的平均年龄为46±17岁,20%患有糖尿病,其中17%未意识到自己的病情(未诊断出的糖尿病),21%患有糖尿病前期。糖尿病与跌倒、弯腰、蹲、跪、完成家务、上下床、长时间站立和坐、举过头顶、抓握物体以及参加社交活动困难显著相关。对于40岁之前被诊断出糖尿病的患者,糖尿病与意识模糊或记忆问题之间的关联更强。只有维生素D水平较低的糖尿病患者报告有记忆问题。维生素A和E水平并未改变糖尿病与跌倒或任何身体功能、意识模糊或记忆问题之间的关联。糖尿病前期仅与长时间站立困难相关。

结论

糖尿病与跌倒、身体功能障碍和参加社交活动困难相关。维生素D水平改变了对意识模糊和记忆问题的影响。

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