School of Public Health, Dalian Medical University, Dalian, 116044, China.
National Institute of Food Science and Technology, University of Agriculture Faisalabad, Faislabad, Pakistan.
Amino Acids. 2018 May;50(5):487-502. doi: 10.1007/s00726-018-2544-4. Epub 2018 Feb 28.
Diets in rats and humans have shown promising results. Taurine improved glucagon activity, promoted glycemic stability, modified glucose levels, successfully addressed hyperglycemia via advanced glycation end-product control, improved insulin secretion and had a beneficial effect on insulin resistance. Taurine treatment performed well against oxidative stress in brain, increased the secretion of required hormones and protected against neuropathy, retinopathy and nephropathy in diabetes compared with the control. Taurine has been observed to be effective in treatments against diabetic hepatotoxicity, vascular problems and heart injury in diabetes. Taurine was shown to be effective against oxidative stress. The mechanism of action of taurine cannot be explained by one pathway, as it has many effects. Several of the pathways are the advanced glycation end-product pathway, PI3-kinase/AKT pathway and mitochondrial apoptosis pathway. The worldwide threat of diabetes underscores the urgent need for novel therapeutic measures against this disorder. Taurine (2-aminoethane sulfonic acid) is a natural compound that has been studied in diabetes and diabetes-induced complications.
在大鼠和人类的饮食中已显示出有前景的结果。牛磺酸改善了胰高血糖素的活性，促进了血糖稳定，通过控制晚期糖基化终产物来调节血糖水平，成功地解决了高血糖问题，改善了胰岛素分泌，对胰岛素抵抗也有有益的影响。牛磺酸在大脑的氧化应激中表现良好，与对照组相比，它增加了所需激素的分泌，并且可以预防糖尿病中的神经病、视网膜病和肾病。牛磺酸已被观察到在治疗糖尿病肝毒性、血管问题和心脏损伤方面是有效的。牛磺酸对氧化应激有效果。牛磺酸的作用机制不能仅通过一条途径来解释，因为它有很多作用。其中一些途径是晚期糖基化终产物途径、PI3-激酶/AKT 途径和线粒体凋亡途径。糖尿病在全球范围内构成威胁，这突显了迫切需要针对这种疾病的新的治疗措施。牛磺酸（2-氨基乙磺酸）是一种已在糖尿病及其引起的并发症中进行研究的天然化合物。
