CD36缺乏减弱饮食对小鼠性腺脂肪组织和肠系膜淋巴结中调节性T细胞的影响。
CD36 deficiency blunts effects of diet on regulatory T cells in murine gonadal adipose tissue and mesenteric lymph nodes.
作者信息
Geys Lotte, Vranckx Christine, Lijnen Henri Roger, Scroyen Ilse
机构信息
KU Leuven, University of Leuven, Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, B-3000 Leuven, Belgium.
KU Leuven, University of Leuven, Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, B-3000 Leuven, Belgium.
出版信息
Cell Immunol. 2015 Nov-Dec;298(1-2):33-6. doi: 10.1016/j.cellimm.2015.08.006. Epub 2015 Sep 1.
The effect of cluster of differentiation (CD)36 on regulatory T cells (Treg) was investigated in gonadal (GN) adipose tissues and mesenteric lymph nodes (MLN) of wild-type (WT) and CD36 deficient (CD36(-/-)) mice kept on standard fat (SFD, lean) or on high fat diet (HFD, obese). GN adipose tissue mass was smaller, but MLN size larger for obese CD36(-/-) versus obese WT mice. Overall, the reduction of Treg cells in GN adipose tissue and MLN after a HFD is much more prominent in WT than CD36(-/-) mice. Moreover, CD36(-/-) mice may be protected against obesity-related chronic inflammation.
在以标准脂肪饮食（SFD，瘦型）或高脂饮食（HFD，肥胖型）饲养的野生型（WT）和CD36缺陷型（CD36(-/-)）小鼠的性腺（GN）脂肪组织和肠系膜淋巴结（MLN）中，研究了分化簇（CD）36对调节性T细胞（Treg）的影响。与肥胖的WT小鼠相比，肥胖的CD36(-/-)小鼠的GN脂肪组织质量较小，但MLN尺寸较大。总体而言，高脂饮食后，WT小鼠的GN脂肪组织和MLN中Treg细胞的减少比CD36(-/-)小鼠更为显著。此外，CD36(-/-)小鼠可能对肥胖相关的慢性炎症具有保护作用。
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