Geys Lotte, Vranckx Christine, Lijnen Henri Roger, Scroyen Ilse
KU Leuven, University of Leuven, Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, B-3000 Leuven, Belgium.
KU Leuven, University of Leuven, Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, B-3000 Leuven, Belgium.
Cell Immunol. 2015 Nov-Dec;298(1-2):33-6. doi: 10.1016/j.cellimm.2015.08.006. Epub 2015 Sep 1.
The effect of cluster of differentiation (CD)36 on regulatory T cells (Treg) was investigated in gonadal (GN) adipose tissues and mesenteric lymph nodes (MLN) of wild-type (WT) and CD36 deficient (CD36(-/-)) mice kept on standard fat (SFD, lean) or on high fat diet (HFD, obese). GN adipose tissue mass was smaller, but MLN size larger for obese CD36(-/-) versus obese WT mice. Overall, the reduction of Treg cells in GN adipose tissue and MLN after a HFD is much more prominent in WT than CD36(-/-) mice. Moreover, CD36(-/-) mice may be protected against obesity-related chronic inflammation.
在以标准脂肪饮食（SFD，瘦型）或高脂饮食（HFD，肥胖型）饲养的野生型（WT）和CD36缺陷型（CD36(-/-)）小鼠的性腺（GN）脂肪组织和肠系膜淋巴结（MLN）中，研究了分化簇（CD）36对调节性T细胞（Treg）的影响。与肥胖的WT小鼠相比，肥胖的CD36(-/-)小鼠的GN脂肪组织质量较小，但MLN尺寸较大。总体而言，高脂饮食后，WT小鼠的GN脂肪组织和MLN中Treg细胞的减少比CD36(-/-)小鼠更为显著。此外，CD36(-/-)小鼠可能对肥胖相关的慢性炎症具有保护作用。
