a Division of Infectious Diseases, Department of Internal Medicine , The University of Texas Health Science Center at Houston , Houston , TX , USA.
b US Department of Agriculture/Agricultural Research Center, Children's Nutrition Research Center, Department of Pediatrics , Baylor College of Medicine , Houston , TX , USA.
Adipocyte. 2019 Dec;8(1):154-163. doi: 10.1080/21623945.2019.1609202.
CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5-40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation.
CD36 是一种多功能的清道夫受体和脂质转运蛋白，与代谢和炎症病理学以及癌症进展有关。已知 CD36 由脂肪细胞和单核细胞/巨噬细胞表达，但 T 细胞是否表达 CD36 尚不清楚。我们发现，人类、猴子和老鼠的脂肪组织和肝脏中的 CD4 和 CD8 T 细胞上调了 CD36 的表达（范围从约 5-40%的 CD36+），而血液、脾脏和淋巴结中的 T 细胞几乎不表达 CD36。CD36 主要由猴子脂肪组织中处于静止状态的 CD38-、HLA.DR-和 PD-1-的 T 细胞表达，并在小鼠高脂喂养期间增加。脂肪组织和肝脏促进驻留 T 细胞呈现出一种独特的表型，其特征是 CD36 的上调。
