化合物Q终于被破解了。
The Q, Compound Q is Finally Deciphered.
作者信息
Bhagi-Damodaran Ambika, Lu Yi
机构信息
Department of Chemistry, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, United States.
出版信息
Inorg Chem Front. 2015;2:824-826. doi: 10.1039/C5QI00117J.
Methane monooxygenases (MMOs) activate the high energy C-H bond of methane and convert it to methanol with high selectivity and under physiological conditions. Despite decades of efforts focusing on elucidating the structure, function and mechanism of soluble MMOs, the structure of a key intermediate (called compound Q) remained unknown. This article highlights a recent report by Banerjee et. al. which not only firmly establishes the core-structure of Q, but also provides significant insight into its formation, reaction with methane and eventual decay.
甲烷单加氧酶（MMOs）能激活甲烷中高能的C-H键，并在生理条件下将其高选择性地转化为甲醇。尽管数十年来一直致力于阐明可溶性MMOs的结构、功能和机制，但关键中间体（称为化合物Q）的结构仍然未知。本文重点介绍了Banerjee等人最近的一篇报告，该报告不仅确定了Q的核心结构，还对其形成、与甲烷的反应以及最终的衰变提供了重要见解。
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