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[测定脑脊液中神经元特异性烯醇化酶（NSE）水平作为脑缺血性中风程度生化指标的实用性。中风大鼠模型的实验研究]

[Usefulness of determining the level of neuron-specific enolase (NSE) in the cerebrospinal fluid as a biochemical indicator of the extent of cerebral ischemic stroke. Experimental study of the rat model of stroke].

作者信息

Kotwica Z, Persson L, Hârdemark H G, Pâhlman S

机构信息

Katedry i Kliniki Neurochirurgii AM w Lodzi.

出版信息

Neurol Neurochir Pol. 1989 May-Jun;23(3):198-202.

PMID:2634819
Abstract

Changes of neuron-specific enolase (NSE) in cerebrospinal fluid after experimental ischaemic stroke caused by middle cerebral artery occlusion in rat were studied. High enzyme levels were found between the second and seventh day after artery occlusion and they correlated well with the extension of infarct seen in histology. NSE levels in cerebrospinal fluid are sensitive and reliable markers of brain tissue damage during the acute phase of ischaemic stroke.

摘要

研究了大鼠大脑中动脉闭塞所致实验性缺血性中风后脑脊液中神经元特异性烯醇化酶（NSE）的变化。在动脉闭塞后第2天至第7天发现酶水平升高，且与组织学所见梗死范围密切相关。脑脊液中NSE水平是缺血性中风急性期脑组织损伤的敏感且可靠的标志物。

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