[Nerve tissue protein S 100 level in the cerebrospinal fluid as an indicator of the extent of brain damage in cerebral ischemic stroke. Experimental study of a rat model of stroke].

The value of S-100 protein as a biochemical marker of the extension of brain damage was studied in a rat model of ischaemic stroke. Increased S-100 levels in cerebrospinal fluid were found between the second and fifth day stroke, and the highest values were noted in animals with largest infarcts. In the acute phase ischaemic stroke S-100 protein in cerebrospinal fluid can be useful as a marker of ischaemic brain damage, but further studies on markers of ischaemic stroke are necessary for better diagnosis of cerebral tissue injury.