Chłopkiewicz B, Anuszewska E
Institute for Drug Research and Control, Warszawa, Poland.
Pol J Pharmacol Pharm. 1989 Jul-Aug;41(4):293-8.
Melphalan and cyclophosphamide, cytostatics used for cancer therapy, were investigated for their ability to induce morphological transformation of embryonic cells of the golden hamster and to evoke structural chromosome aberrations. The antimitotic action of both drugs was also investigated. Cyclophosphamide, under conditions in which it did not produce either structural chromosomal aberrations or exerted cytotoxic action, induced morphological transformation of hamster cells. Under the experimental conditions melphalan induced morphological transformation of hamster cells at concentrations not inducing chromosomal aberrations.
美法仑和环磷酰胺是用于癌症治疗的细胞抑制剂，对它们诱导金黄地鼠胚胎细胞形态转化及引发染色体结构畸变的能力进行了研究。同时也研究了这两种药物的抗有丝分裂作用。在既不产生染色体结构畸变也不发挥细胞毒性作用的条件下，环磷酰胺诱导了仓鼠细胞的形态转化。在实验条件下，美法仑在不诱导染色体畸变的浓度下诱导了仓鼠细胞的形态转化。
