Deysson G, Adolphe M, Semont H
C R Seances Soc Biol Fil. 1981;175(2):182-6.
N-mustard diamide phosphoric and above all 4-hydroperoxycyclophosphamide are clearly more cytotoxic than same kind, which is in accordance with the fact that these compounds are the active metabolites of cyclophosphamide. On the contrary, 4-ketocyclophosphamide and carboxyphosphamide, secondary metabolites inapt to be activated, are not more cytotoxic than cyclophosphamide. No tolerance does occur with these metabolites, contrary to cyclophosphamide itself.
N-二酰胺磷酰氮芥，尤其是4-氢过氧环磷酰胺，其细胞毒性明显高于同类物质，这与这些化合物是环磷酰胺的活性代谢产物这一事实相符。相反，4-酮环磷酰胺和羧基磷酰胺作为不易被激活的次级代谢产物，其细胞毒性并不比环磷酰胺更强。与环磷酰胺本身不同，这些代谢产物不会产生耐受性。
