Drabczyńska A, Pawłowski M, Gorczyca M, Malec D, Modzelewski J
Department of Pharmaceutical Chemistry, Medical Academy, Kraków, Poland.
Pol J Pharmacol Pharm. 1989 Jul-Aug;41(4):385-94.
Methods of synthesis, chemical properties and results of preliminary pharmacological screening for 8-amino substituted derivatives of caffeine (1-3) and 7,8-disubstituted derivatives of 8-aminotheophylline (8-12) have been described. The compounds show weak sedative and antidepressive activity and some of them (2, 10, 12) also small antinociceptive effect.
已描述了咖啡因8-氨基取代衍生物（1-3）和8-氨基茶碱7,8-二取代衍生物（8-12）的合成方法、化学性质及初步药理筛选结果。这些化合物显示出较弱的镇静和抗抑郁活性，其中一些化合物（2、10、12）还具有较小的抗伤害感受作用。
