通过自由基迁移实现（±）-戈米辛的全合成。
Total Synthesis of (±)-Goniomitine via Radical Translocation.
机构信息
Department of Chemistry, Oregon State University , 153 Gilbert Hall, Corvallis, Oregon 97331, United States.
出版信息
Org Lett. 2015 Sep 18;17(18):4558-60. doi: 10.1021/acs.orglett.5b02277. Epub 2015 Sep 8.
PMID:26348647
Abstract
The aspidosperma alkaloid goniomitine was synthesized in six steps from 2-ethyl-δ-valerolactam. The convergent strategy features an Ullman coupling to assemble the required carbon atoms. A complexity-generating radical translocation reaction was used to build the indole architecture.
摘要
从 2-乙基-δ-戊内酰胺出发，经六步反应合成了石蒜科生物碱高尼米汀。该合成策略采用 Ullman 偶联反应来构建所需的碳原子，利用产生复杂结构的自由基迁移反应构建吲哚环系。
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