Kadono Yoshifumi, Ueno Satoru, Kadomoto Suguru, Iwamoto Hiroaki, Takezawa Yuta, Nakashima Kazufumi, Nohara Takahiro, Izumi Kouji, Mizokami Atsushi, Gabata Toshifumi, Namiki Mikio
Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Department of Radiology, Kanazawa University School of Medicine, Kanazawa, Japan.
Neurourol Urodyn. 2016 Nov;35(8):1034-1039. doi: 10.1002/nau.22877. Epub 2015 Sep 9.
To examine which preoperative factors, including urodynamic evaluations, and operative procedures could predict continence status after robot-assisted radical prostatectomy (RARP) in this study.
Univariate and multivariate logistic regression analyses of preoperative factors such as age, body mass index, prostate-specific antigen level before biopsy, prostate size before surgery, membranous urethral length measured using magnetic resonance imaging (MRI), bladder compliance and maximum urethral closure pressure (MUCP) measured by urodynamic study (UDS), and nerve-sparing (NS) status predicting 24-hr pad test >2 g/day at 1 year after RARP were examined in 111 patients enrolled in this study.
The number of patients with incontinence at 1 year after RARP was 39 (35.1%). The only predictive factor for urinary continence was NS grades. To investigate the contribution of NS to urinary continence, 84 patients underwent UDS three times; before, immediately after, and 1 year after RARP. Chronological UDS revealed that recovery patterns of storage and voiding functions were the same among non-NS, unilateral-NS, and bilateral-NS groups, and that higher degrees of NS contributed to lesser decreases in MUCP and longer functional urethral length (FUL) after RARP.
Preoperative factors, including the results of UDS, could not predict continence 1 year after RARP. The NS procedure contributed to continence status. NS favorably affected MUCP and FUL; however, it did not affect bladder function after RARP. Neurourol. Urodynam. 35:1034-1039, 2016. © 2015 Wiley Periodicals, Inc.
在本研究中,探讨哪些术前因素(包括尿动力学评估)及手术操作能够预测机器人辅助根治性前列腺切除术(RARP)后的控尿状态。
对111例本研究纳入患者的术前因素进行单因素和多因素逻辑回归分析,这些因素包括年龄、体重指数、活检前前列腺特异性抗原水平、手术前前列腺大小、使用磁共振成像(MRI)测量的膜部尿道长度、膀胱顺应性以及通过尿动力学研究(UDS)测量的最大尿道闭合压(MUCP),还有预测RARP术后1年24小时尿垫试验>2g/天的保留神经(NS)状态。
RARP术后1年尿失禁患者数量为39例(35.1%)。尿控的唯一预测因素是NS分级。为研究NS对尿控的作用,84例患者在RARP术前、术后即刻及术后1年进行了3次UDS检查。时间顺序的UDS显示,非NS组、单侧NS组和双侧NS组储存和排尿功能的恢复模式相同,且更高程度的NS有助于RARP术后MUCP降低幅度更小以及功能性尿道长度(FUL)更长。
包括UDS结果在内的术前因素无法预测RARP术后1年的控尿情况。NS手术有助于控尿状态。NS对MUCP和FUL有积极影响;然而,它对RARP术后的膀胱功能没有影响。《神经泌尿学与尿动力学》35:1034 - 1039, 2016。© 2015威利期刊公司。