Tilson H A, Chamberlain J H, Gylys J A
Pharmacol Biochem Behav. 1977 Jun;6(6):627-30. doi: 10.1016/0091-3057(77)90086-7.
Rats selected for their low performance baselines in an active avoidance shuttle box task were given various doses of R-(-)-2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane (BL-3912A), S-amphetamine or piracetam. BL-3912A at 1 mg/kg IP had no significant behavioral effects, while 5 and 10 mg/kg significantly increased the number of avoidance responses without affecting responses during the intertrial interval (ITI). Statistically reliable effects on behavior were not observed following 20 mg/kg of BL-3912A. S-Amphetamine at 0.5 and 1 mg/kg IP also facilitated avoidance responding, but could be differentiated from BL-3912A in that the S-amphetamine significantly increased shuttles during the ITI. S-Amphetamine at 0.1 mg/kg was not effective, while 2 mg/kg increased ITI activity. Piracetam (50 or 200 mg/kg) had no significant effects on avoidance or shuttles during ITI. Using an electric shock titration procedure, BL-3912A at 10 and 20 mg/kg IP had no significant effect on reaction thresholds. Animals receiving 100 mg/kg of p-chlorophenylalanine po for 3 days and tested 2 days later showed hyperalgesia to the electric shock. In summary, BL-3912A facilitated shuttle box avoidance responding of rats with low performance baselines. Behavioral facilitation occurred without concomitant increases in noncontingent activity or apparent changes in reactivity to electric footshock.
在主动回避穿梭箱任务中，选择表现基线较低的大鼠，给予它们不同剂量的R-(-)-2-氨基-1-(2,5-二甲氧基-4-甲基苯基)丁烷（BL-3912A）、S-苯丙胺或吡拉西坦。腹腔注射1mg/kg的BL-3912A没有显著的行为影响，而5mg/kg和10mg/kg显著增加了回避反应的次数，且不影响试验间隔期（ITI）的反应。20mg/kg的BL-3912A给药后未观察到对行为有统计学上可靠的影响。腹腔注射0.5mg/kg和1mg/kg的S-苯丙胺也促进了回避反应，但与BL-3912A的区别在于，S-苯丙胺显著增加了ITI期间的穿梭次数。0.1mg/kg的S-苯丙胺无效，而2mg/kg增加了ITI期间的活动。吡拉西坦（50或200mg/kg）对ITI期间的回避或穿梭没有显著影响。使用电击滴定程序，腹腔注射10mg/kg和20mg/kg的BL-3912A对反应阈值没有显著影响。口服100mg/kg对氯苯丙氨酸3天并在2天后进行测试的动物对电击表现出痛觉过敏。总之，BL-3912A促进了表现基线较低的大鼠在穿梭箱中的回避反应。行为促进发生时，非条件性活动没有随之增加，对足部电击的反应性也没有明显变化。
