Tilson H A, Chamberlain J H, Gylys J A
Psychopharmacology (Berl). 1977 Jan 31;51(2):169-73. doi: 10.1007/BF00431735.
The behavioral effects of R-2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane or BL-3912A were compared with those of S-Amphetamine and R-DOM. BL-3912A facilitated acquisition of shuttle box responding by rats without increasing noncontingent intertrial (ITI) activity, while S-Amphetamine increased both avoidance and ITI responding. R-DOM had a biphasic effect on avoidance responding, increasing it at low doses and disrupting at higher doses. At doses that facilitated shuttle box responding, BL-3912A had no effect on unacclimated motor activity of rats nor on the rate of continuous avoidance responding by rats. S-Amphetamine increased the frequency of both motor activity and operant avoidance responding, while R-DOM decreased motor activity and increased operant avoidance responding. By facilitating avoidance behavior without increasing othermeasures of psychomotor activity, BL-3912A represents a unique psychopharmacological agent clearly different from R-DOM and S-Amphetamine.
将R-2-氨基-1-(2,5-二甲氧基-4-甲基苯基)丁烷或BL-3912A的行为效应与S-苯丙胺和R-DOM的行为效应进行了比较。BL-3912A促进大鼠穿梭箱反应的习得，同时不增加非偶然性的试验间期（ITI）活动，而S-苯丙胺则增加回避反应和ITI反应。R-DOM对回避反应有双相作用，低剂量时增加回避反应，高剂量时则破坏回避反应。在促进穿梭箱反应的剂量下，BL-3912A对未适应的大鼠运动活动以及大鼠连续回避反应的速率均无影响。S-苯丙胺增加运动活动频率和操作性回避反应，而R-DOM降低运动活动并增加操作性回避反应。通过促进回避行为而不增加其他精神运动活动指标，BL-3912A代表了一种明显不同于R-DOM和S-苯丙胺的独特精神药理学药物。
