El Menchawy Imane, El Hamdouchi Asmaa, El Kari Khalid, Saeid Naima, Zahrou Fatima Ezzahra, Benajiba Nada, El Harchaoui Imane, El Mzibri Mohamed, El Haloui Noureddine, Aguenaou Hassan
Joint Unit of Nutrition and Food Research (URAC39), Ibn Tofaïl University-CNESTEN, Regional Designated Center for Nutrition (AFRA/IAEA), Kenitra, 14000 Rabat, Morocco.
J Nutr Metab. 2015;2015:690954. doi: 10.1155/2015/690954. Epub 2015 Aug 19.
Iron deficiency constitutes a major public health problem in Morocco, mainly among women and children. The aim of our paper is to assess the efficacy of consumption of multiple micronutrients (MMN) fortified milk on iron status of Moroccan schoolchildren living in rural region. Children (N = 195), aged 7 to 9 y, were recruited from schools and divided into two groups: the nonfortified group (NFG) received daily a nonfortified Ultra-High-Temperature (UHT) milk and the fortified group received (FG) daily UHT milk fortified with multiple micronutrients including iron sulfate. Blood samples were collected at baseline (T0) and after 9 months (T9). Hemoglobin (Hb) was measured in situ by Hemocue device; ferritin and C Reactive Protein were assessed in serum using ELISA and nephelometry techniques, respectively. Results were considered significant when the p value was <0.05. At T9 FG showed a reduction of iron deficiency from 50.9% to 37.2% (p = 0.037). Despite the low prevalence of iron deficiency anemia (1.9%); more than 50% of children in our sample suffered from iron deficiency at baseline. The consumption of fortified milk reduced the prevalence of iron deficiency by 27% in schoolchildren living in high altitude rural region of Morocco. Clinical Trial Registration. Our study is registered in the Pan African Clinical Trial Registry with the identification number PACTR201410000896410.
缺铁是摩洛哥的一个主要公共卫生问题,主要影响妇女和儿童。本文的目的是评估食用多种微量营养素(MMN)强化牛奶对摩洛哥农村地区学童铁状况的影响。从学校招募了195名7至9岁的儿童,并将其分为两组:未强化组(NFG)每天饮用未强化的超高温(UHT)牛奶,强化组(FG)每天饮用添加了包括硫酸铁在内的多种微量营养素的UHT强化牛奶。在基线期(T0)和9个月后(T9)采集血样。血红蛋白(Hb)通过Hemocue设备现场测量;铁蛋白和C反应蛋白分别采用ELISA和比浊法在血清中进行评估。当p值<0.05时,结果被认为具有统计学意义。在T9时,FG组的缺铁率从50.9%降至37.2%(p = 0.037)。尽管缺铁性贫血的患病率较低(1.9%);但我们样本中超过50%的儿童在基线时存在缺铁情况。食用强化牛奶使摩洛哥高海拔农村地区学童的缺铁患病率降低了27%。临床试验注册。我们的研究已在泛非临床试验注册中心注册,识别号为PACTR201410000896410。