Solon Florentino S, Sarol Jesus N, Bernardo Allan B I, Solon Juan Antonio A, Mehansho Haile, Sanchez-Fermin Liza E, Wambangco Lorena S, Juhlin Kenton D
Nutrition Center of the Philippines, Western Bicutan, Taguig, Metro Manila.
Food Nutr Bull. 2003 Dec;24(4 Suppl):S129-40. doi: 10.1177/15648265030244S210.
This study aimed to determine the effect of a multiple-micronutrient-fortified beverage on the micronutrient status, physical fitness, and cognitive performance of schoolchildren. The study was a randomized, double-blind, placebo-controlled trial of schoolchildren assigned to receive either the fortified or nonfortified beverage with or without anthelmintic therapy. Data on hemoglobin level, urinary iodine excretion (UIE) level, physical fitness, and cognitive performance were collected at baseline and at 16 weeks post-intervention. The fortified beverage significantly improved iron status among the subjects that had hemoglobin levels < 11 g/dl at baseline. The proportion of children who remained moderately to severely anemic was significantly lower among those given the fortified beverage. In the groups that received the fortified product, the median UIE level increased, whereas among those who received the placebo beverage, the median UIE level was reduced significantly. Iron- and/or iodine-deficient subjects who received the fortified beverage showed significant improvements in fitness (post-exercise reduction of heart rate) and cognitive performance (nonverbal mental ability score). The study showed that consumption of a multiple-micronutrient-fortified beverage for 16 weeks had significant effects on iron status, iodine status, physical fitness, and cognitive performance among iron- and/or iodine-deficient Filipino schoolchildren. Anthelmintic therapy improved iron status of anemic children and iodine status of the iron-adequate children at baseline but it had no effect on physical fitness and cognitive performance. The results from the clinical study showed that a multiple-micronutrient-fortified beverage could play an important role in preventing and controlling micronutrient deficiencies.
本研究旨在确定一种多种微量营养素强化饮料对学童微量营养素状况、身体素质和认知能力的影响。该研究是一项针对学童的随机、双盲、安慰剂对照试验，这些学童被分配接受强化或未强化饮料，并接受或不接受驱虫治疗。在基线和干预后16周收集了血红蛋白水平、尿碘排泄（UIE）水平、身体素质和认知能力的数据。强化饮料在基线时血红蛋白水平<11 g/dl的受试者中显著改善了铁状况。接受强化饮料的儿童中，中度至重度贫血的比例显著较低。在接受强化产品的组中，UIE水平中位数增加，而在接受安慰剂饮料的组中，UIE水平中位数显著降低。接受强化饮料的铁和/或碘缺乏受试者在身体素质（运动后心率降低）和认知能力（非语言智力得分）方面有显著改善。该研究表明，对于铁和/或碘缺乏的菲律宾学童，饮用多种微量营养素强化饮料16周对铁状况、碘状况、身体素质和认知能力有显著影响。驱虫治疗改善了贫血儿童的铁状况和基线时铁充足儿童的碘状况，但对身体素质和认知能力没有影响。临床研究结果表明，多种微量营养素强化饮料在预防和控制微量营养素缺乏方面可发挥重要作用。
