Menz Veera Katharina, Schaffelhofer Stefan, Scherberger Hansjörg
German Primate Center GmbH, D-37077 Göttingen, Germany.
J Neural Eng. 2015 Oct;12(5):056016. doi: 10.1088/1741-2560/12/5/056016. Epub 2015 Sep 10.
In the last decade, multiple brain areas have been investigated with respect to their decoding capability of continuous arm or hand movements. So far, these studies have mainly focused on motor or premotor areas like M1 and F5. However, there is accumulating evidence that anterior intraparietal area (AIP) in the parietal cortex also contains information about continuous movement.
In this study, we decoded 27 degrees of freedom representing complete hand and arm kinematics during a delayed grasping task from simultaneously recorded activity in areas M1, F5, and AIP of two macaque monkeys (Macaca mulatta).
We found that all three areas provided decoding performances that lay significantly above chance. In particular, M1 yielded highest decoding accuracy followed by F5 and AIP. Furthermore, we provide support for the notion that AIP does not only code categorical visual features of objects to be grasped, but also contains a substantial amount of temporal kinematic information.
This fact could be utilized in future developments of neural interfaces restoring hand and arm movements.
在过去十年中，多个脑区已就其对连续手臂或手部运动的解码能力进行了研究。到目前为止，这些研究主要集中在运动或运动前区，如M1和F5。然而，越来越多的证据表明，顶叶皮层中的前顶内区（AIP）也包含有关连续运动的信息。
在本研究中，我们从两只猕猴（恒河猴）的M1、F5和AIP区域同时记录的活动中，解码了在延迟抓握任务期间代表完整手部和手臂运动学的27个自由度。
我们发现所有这三个区域提供的解码性能都显著高于随机水平。特别是，M1产生了最高的解码准确率，其次是F5和AIP。此外，我们支持这样一种观点，即AIP不仅编码要抓握物体的分类视觉特征，还包含大量的时间运动学信息。
这一事实可用于未来恢复手部和手臂运动的神经接口的开发。
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