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“优质医疗,合理价值”处方政策对英国基层医疗中使用血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂治疗高血压的影响:纵向准实验设计

The impact of the 'Better Care Better Value' prescribing policy on the utilisation of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for treating hypertension in the UK primary care setting: longitudinal quasi-experimental design.

作者信息

Baker Amanj, Chen Li-Chia, Elliott Rachel A, Godman Brian

机构信息

Division for Social Research in Medicines and Health, School of Pharmacy, University of Nottingham, East Drive, University Park, Nottingham, NG7 2RD, UK.

Department of Pharmacology, College of Pharmacy, Hawler Medical University, Erbil, Iraq.

出版信息

BMC Health Serv Res. 2015 Sep 10;15:367. doi: 10.1186/s12913-015-1013-y.

Abstract

BACKGROUND

In April/2009, the UK National Health Service initiated four Better Care Better Value (BCBV) prescribing indicators, one of which encouraged the prescribing of cheaper angiotensin-converting enzyme inhibitors (ACEIs) instead of expensive angiotensin receptor blockers (ARBs), with 80 % ACEIs/20 % ARBs as a proposed, and achievable target. The policy was intended to save costs without affecting patient outcomes. However, little is known about the actual impact of the BCBV indicator on ACEIs/ARBs utilisation and cost-savings. Therefore, this study aimed to evaluate the impact of BCBV policy on ACEIs/ARBs utilisation and cost-savings, including exploration of regional variations of the policy's impact.

METHODS

This cross-sectional study used data from the UK Clinical Practice Research Datalink. Segmented time-series analysis was applied to monthly ACEIs prescription proportion, adjusted number of ACEIs/ARBs prescriptions and costs.

RESULTS

Overall, the proportion of ACEIs prescription decreased during the study period from 71.2% in April/2006 to 70.7% in March/2012, with a small but a statistically significant pre-policy reduction in its monthly trend of 0.02% (p < 0.001). Instantly after its initiation, the policy was associated with a sudden reduction in the proportion of ACEIs prescription; however, it resulted in a statistically significant increase in the post-policy monthly trend of ACEIs prescription proportion of 0.013% (p < 0.001), resulting in an overall post-policy slope of -0.007%. Despite this post-policy induced increment, the policy failed to achieve the 80% target, which resulted in missing a potential cost-saving opportunity. The pre-policy trend of the adjusted number of ACEIs/ARBs prescriptions was increasing; however, their trends declined after the policy implementation. The policy affected neither total ACEIs/ARBs cost nor individual ACEIs or ARBs costs.

CONCLUSIONS

ACEIs/ARBs utilisation was not affected by the BCBV policy. The small increase in post-policy ACEIs prescription proportion was not associated with any savings. This study represents a case study of a failed or ineffective policy and thus provides key learning lessons for other healthcare authorities. Given the existing opportunity of potential cost-savings from achieving the 80 % target, specific measures would be needed to enhance the policy implementation and uptake; however, this must be balanced against other cost-saving policies in other high-priority areas.

摘要

背景

2009年4月,英国国民医疗服务体系启动了四项“更佳护理,更佳价值”(BCBV)处方指标,其中一项鼓励开具更便宜的血管紧张素转换酶抑制剂(ACEI)而非昂贵的血管紧张素受体阻滞剂(ARB),提议并设定了80%使用ACEI/20%使用ARB的可实现目标。该政策旨在在不影响患者治疗效果的情况下节省成本。然而,关于BCBV指标对ACEI/ARB使用情况和成本节约的实际影响知之甚少。因此,本研究旨在评估BCBV政策对ACEI/ARB使用情况和成本节约的影响,包括探讨该政策影响的地区差异。

方法

这项横断面研究使用了来自英国临床实践研究数据链的数据。对每月ACEI处方比例、ACEI/ARB处方调整数量和成本进行分段时间序列分析。

结果

总体而言,在研究期间,ACEI处方比例从2006年4月的71.2%降至2012年3月的70.7%,在政策实施前其月度趋势有小幅但具有统计学意义的下降,降幅为0.02%(p<0.001)。政策实施后,ACEI处方比例立即突然下降;然而,政策实施后ACEI处方比例的月度趋势出现了具有统计学意义的上升,升幅为0.013%(p<0.001),导致政策实施后的总体斜率为-0.007%。尽管政策实施后出现了这一增长,但该政策未能实现80%的目标,从而错失了一个潜在的成本节约机会。ACEI/ARB处方调整数量的政策实施前趋势呈上升趋势;然而,在政策实施后其趋势下降。该政策对ACEI/ARB总成本以及单个ACEI或ARB成本均无影响。

结论

ACEI/ARB的使用情况未受BCBV政策影响。政策实施后ACEI处方比例的小幅上升并未带来任何成本节约。本研究是一个政策失败或无效的案例研究,因此为其他医疗保健机构提供了关键的经验教训。鉴于实现80%目标存在潜在的成本节约机会,需要采取具体措施来加强政策的实施和推广;然而,这必须与其他高优先领域的其他成本节约政策相平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40fc/4566432/8d286b8c6b05/12913_2015_1013_Fig1_HTML.jpg

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