Chaudhary Preeti Madhukar, Sangabathuni Sivakoti, Murthy Raghavendra Vasudeva, Paul Ajay, Thulasiram Hirekodathakallu V, Kikkeri Raghavendra
Indian Institute of Science Education and Research, Pashan, Pune 411008, India.
Chem Commun (Camb). 2015 Nov 7;51(86):15669-72. doi: 10.1039/c5cc05238f.
Achieving selective and sensitive carbohydrate-protein interactions (CPIs) using nanotechnology is an intriguing area of research. Here we demonstrate that the different shapes of gold nanoparticles (AuNPs) functionalized with monosaccharides tune the bacterial aggregations. The mechanism of aggregation revealed that the large number of surface interactions of rod shaped mannose-AuNPs with E. coli ORN 178 compared with spherical and star-shaped AuNPs exhibited higher avidity and sensitivity. Moreover, such sensitive binding can be used for effective inhibition of bacterial infection of cells.
利用纳米技术实现选择性和灵敏的碳水化合物-蛋白质相互作用（CPI）是一个有趣的研究领域。在此，我们证明了用单糖功能化的不同形状的金纳米颗粒（AuNP）可调节细菌聚集。聚集机制表明，与球形和星形AuNP相比，棒状甘露糖-AuNP与大肠杆菌ORN 178的大量表面相互作用表现出更高的亲和力和灵敏度。此外，这种灵敏的结合可用于有效抑制细胞的细菌感染。
Zotero 插件