Kveton Filip, Blsakova Anna, Kasak Peter, Tkac Jan
Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, Slovakia.
Center for Advanced Materials, Qatar University, Doha 2713, Qatar.
Nanomaterials (Basel). 2020 Jul 19;10(7):1406. doi: 10.3390/nano10071406.
This review paper comprehensively summarizes advances made in the design of glycan nanobiosensors using diverse forms of nanomaterials. In particular, the paper covers the application of gold nanoparticles, quantum dots, magnetic nanoparticles, carbon nanoparticles, hybrid types of nanoparticles, proteins as nanoscaffolds and various nanoscale-based approaches to designing such nanoscale probes. The article covers innovative immobilization strategies for the conjugation of glycans on nanoparticles. Summaries of the detection schemes applied, the analytes detected and the key operational characteristics of such nanobiosensors are provided in the form of tables for each particular type of nanomaterial.
这篇综述文章全面总结了使用多种形式的纳米材料设计聚糖纳米生物传感器所取得的进展。特别是，本文涵盖了金纳米颗粒、量子点、磁性纳米颗粒、碳纳米颗粒、纳米颗粒混合类型、作为纳米支架的蛋白质以及各种基于纳米尺度的方法在设计此类纳米探针中的应用。文章介绍了用于将聚糖缀合到纳米颗粒上的创新固定策略。针对每种特定类型的纳米材料，以表格形式提供了所应用的检测方案、检测的分析物以及此类纳米生物传感器的关键操作特性的总结。
