Graeff E O, Hunziker M H, Graeff F G
Departamento de Psicologia Experimental, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1989;22(9):1141-4.
The effects of the 5-hydroxytryptamine-1A (5-HT1A) receptor agonists on the learned helplessness test were investigated. Rats were submitted to a single session of 60 uncontrollable shocks (10-s duration, 1.0 mA, every 60 +/- 40 s) and then treated twice daily with ip injections of either ipsapirone (13 mg/kg daily) or BAY R 1531 (0.375 mg/kg daily) for four consecutive days. On the last day, the animals were submitted to an escape test. The results showed that both drug treatments blocked the deficit in the escape learning (helplessness effect). These data suggest that drugs which stimulate 5-HT1A receptors have an antidepressant-like activity in this animal model of depression.
研究了5-羟色胺1A（5-HT1A）受体激动剂对习得性无助试验的影响。将大鼠单次给予60次不可控电击（持续10秒，1.0毫安，每60±40秒一次），然后连续四天每天两次腹腔注射ipsapirone（每日13毫克/千克）或BAY R 1531（每日0.375毫克/千克）进行治疗。在最后一天，对动物进行逃避试验。结果表明，两种药物治疗均阻断了逃避学习中的缺陷（无助效应）。这些数据表明，在这种抑郁症动物模型中，刺激5-HT1A受体的药物具有抗抑郁样活性。
