2,2'-O-[2,2'-二乙酰氨基-2,3,2',3'-四脱氧-6,6'-二-O-(2-十四烷基十六烷酰基)-α,α'-海藻糖-3,3'-二基]双(N-D-乳酰-L-丙氨酰-D-异谷氨酰胺)的合成及免疫佐剂活性
Synthesis and immunoadjuvant activity of 2,2'-O-[2,2'-diacetamido-2,3,2',3'-tetradeoxy-6,6'-di-O-(2-tetradecyl- hexadecanoyl)-alpha,alpha'-trehalose-3,3'-diyl]bis(N-D-lactoyl-L-alanyl -D-isoglutamine).
作者信息
Ishida H, Imai Y, Kiso M, Hasegawa A, Sakurai T, Azuma I
机构信息
Department of Applied Bioorganic Chemistry, Gifu University, Japan.
出版信息
Carbohydr Res. 1989 Dec 21;195(1):59-66. doi: 10.1016/0008-6215(89)85088-8.
PMID:2636046
Abstract
The disaccharide of 6-O-(2-tetradecylhexadecanoyl)muramoyl dipeptide coupled through an alpha-(1----1)-alpha linkage, named in the title, and an analog bearing a single peptide moiety, have been synthesized from 2,2'-diazido-2,2'-dideoxy-alpha,alpha'-trehalose. The immunoadjuvant activities of the products were examined.
摘要
通过α-(1→1)-α键偶联的6-O-(2-十四烷基十六烷酰基)胞壁酰二肽二糖（标题中命名）以及带有单个肽部分的类似物，已由2,2'-二叠氮基-2,2'-二脱氧-α,α'-海藻糖合成。对产物的免疫佐剂活性进行了检测。
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