一种用于一氧化氮和抗癌药物共递送的高效S-NO-聚倍半硅氧烷纳米平台。
An efficient S-NO-polysilsesquioxane nano-platform for the co-delivery of nitric oxide and an anticancer drug.
作者信息
Wang Meng-Ren, Chiu Shih-Jiuan, Chou Hung-Chang, Hu Teh-Min
机构信息
School of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan, Republic of China.
出版信息
Chem Commun (Camb). 2015 Nov 7;51(86):15649-52. doi: 10.1039/c5cc06087g.
PMID:26360641
Abstract
Codelivery of nitric oxide (NO) and drugs based on a single nanocarrier is a promising therapeutic strategy. Here, we report a one-step nanoprecipitation method to generate nanoparticles that possess simultaneous NO-donating and doxorubicin releasing properties. S-Nitroso polysilsesquioxane acts like an avid "drug sponge" that attracts drug molecules into nanospheres.
摘要
基于单一纳米载体共递送一氧化氮（NO）和药物是一种很有前景的治疗策略。在此，我们报告一种一步纳米沉淀法来制备具有同时释放NO和阿霉素特性的纳米颗粒。S-亚硝基聚倍半硅氧烷就像一个贪婪的“药物海绵”，可将药物分子吸引到纳米球中。
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