Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, USA.
Department of Chemistry, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Republic of Korea.; Center for Self-assembly and Complexity, Institute for Basic Science, 77 Cheongam-ro, Nam-gu, Pohang 790-784, Republic of Korea.
J Control Release. 2017 Oct 10;263:223-230. doi: 10.1016/j.jconrel.2016.12.026. Epub 2016 Dec 26.
Chemotherapeutic drugs have made significant contributions to anticancer therapy, along with other therapeutic methods including surgery and radiotherapy over the past century. However, multidrug resistance (MDR) of cancer cells has remained as a significant obstacle in the achievement of efficient chemotherapy. Recently, there has been increasing evidence for the potential function of nitric oxide (NO) to overcome MDR. NO is an endogenous and biocompatible molecule, contrasting with other potentially toxic chemosensitizing agents that reverse MDR effects, which has raised expectations in the development of efficient therapeutics with low side effects. In particular, nanoparticle-based drug delivery systems not only facilitate the delivery of multiple therapeutic agents, but also help bypass MDR pathways, which are conducive for the efficient delivery of NO and anticancer drugs, simultaneously. Therefore, this review will discuss the mechanism of NO in overcoming MDR and recent progress of combined NO and drug delivery systems.
在过去的一个世纪中，化疗药物与手术和放疗等其他治疗方法一起，为癌症治疗做出了重大贡献。然而，癌细胞的多药耐药性 (MDR) 仍然是实现有效化疗的重大障碍。最近，越来越多的证据表明一氧化氮 (NO) 具有克服 MDR 的潜在功能。NO 是一种内源性和生物相容性分子，与其他可能有毒的化学增敏剂逆转 MDR 作用形成对比，这为开发副作用低的高效治疗方法带来了期望。特别是，基于纳米粒子的药物传递系统不仅有助于递送多种治疗剂，而且有助于绕过 MDR 途径，这有利于有效地递送 NO 和抗癌药物。因此，本综述将讨论 NO 克服 MDR 的机制以及最近的 NO 与药物传递系统联合应用的进展。
