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一氧化氮递送在基于纳米颗粒的肿瘤靶向给药与治疗中的应用。

The application of nitric oxide delivery in nanoparticle-based tumor targeting drug delivery and treatment.

作者信息

Qin Lin, Gao Huile

机构信息

Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, China.

出版信息

Asian J Pharm Sci. 2019 Jul;14(4):380-390. doi: 10.1016/j.ajps.2018.10.005. Epub 2018 Nov 22.

DOI:10.1016/j.ajps.2018.10.005
PMID:32104467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7042479/
Abstract

Nitric oxide (NO) shows great role in tumor biology. Recent years, more and more researches utilized NO donor in tumor targeting drug delivery and treatment. In this review, we summarized the NO donors by their endogenous and exogenous stimuli. Then the application of NO donors, which was the main aim of the review, was discussed in detailed according to their functions, including inducing tumor cell apoptosis, reversing tumor multidrug resistance, inhibiting tumor metastasis and improving drug delivery.

摘要

一氧化氮（NO）在肿瘤生物学中发挥着重要作用。近年来，越来越多的研究将NO供体用于肿瘤靶向给药和治疗。在本综述中，我们根据内源性和外源性刺激对NO供体进行了总结。然后，根据其功能详细讨论了NO供体的应用，这也是本综述的主要目的，包括诱导肿瘤细胞凋亡、逆转肿瘤多药耐药性、抑制肿瘤转移和改善药物递送。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/12bd622815ca/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/6e78df25a437/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/fb6052525caf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/f812e429349e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/7168aff4f502/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/2d9a8df1674a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/12bd622815ca/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/6e78df25a437/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/fb6052525caf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/f812e429349e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/7168aff4f502/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/2d9a8df1674a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d30/7042479/12bd622815ca/gr5.jpg

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