妊娠期胃食管反流病的食管外症状

Extraesophageal symptoms of gastroesophageal reflux disease during pregnancy.

作者信息

Malfertheiner M, Malfertheiner P, Costa S D, Pfeifer M, Ernst W, Seelbach-Göbel B, Fill Malfertheiner S

机构信息

Innere Medizin 2, Universitätsklinikum Regensburg, Germany.

Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum Magdeburg, Germany.

出版信息

Z Gastroenterol. 2015 Sep;53(9):1080-3. doi: 10.1055/s-0034-1399453. Epub 2015 Sep 14.

DOI:10.1055/s-0034-1399453

PMID:26367023

Abstract

AIM

Typical symptoms of gastroesophageal reflux disease (GERD) are known to be frequent in pregnancy. The aim of this study was to gain a first estimation of the occurrence of extraesophageal symptoms in this context.

METHODS

A prospective longitudinal study was performed on 166 pregnant women and in a control group of 285 women. The diagnosis of GERD was based on the Montreal classification using the reflux disease questionnaire (RDQ). Extraesophageal symptoms were recorded with a self-administered questionnaire. Typical GERD symptoms and extraesophageal GERD symptoms were recorded in each trimester of pregnancy.

RESULTS

The prevalence of GERD during pregnancy was 16.9% in the first, 25.3% in the second and 51.2% in the third trimester. The prevalence of GERD in the control group was 6.3%. Asthma was reported by 3.5% of controls and by 6% of pregnant women during pregnancy. Chest pain occurred in 6% of the controls and in 1.8%, 2.4% and 2.4% during the trimesters of pregnancy, chronic cough was reported by 1.1% of controls and 1.2% of pregnant women. With the diagnosis of GERD the odds ratios and 95% confidence intervals for asthma, chronic cough and chest pain in the third trimester of pregnancy were as follows: 1.56 (0.58-4.22) for asthma, 0.91 (0.08-10.28) for chronic cough and 2.04 (0.49-8.46) for chest pain.

CONCLUSION

GERD is very frequent during pregnancy with progressive incidence during the course of pregnancy. Extraesophageal symptoms of GERD have an unexpected low prevalence during pregnancy.

摘要

目的

已知胃食管反流病（GERD）的典型症状在孕期很常见。本研究的目的是首次评估在这种情况下食管外症状的发生率。

方法

对166名孕妇和285名女性对照组进行了一项前瞻性纵向研究。GERD的诊断基于使用反流病问卷（RDQ）的蒙特利尔分类法。食管外症状通过自行填写的问卷进行记录。在孕期的每个阶段记录典型的GERD症状和食管外GERD症状。

结果

孕期GERD的患病率在孕早期为16.9%，孕中期为25.3%，孕晚期为51.2%。对照组中GERD的患病率为6.3%。在孕期，3.5%的对照组女性和6%的孕妇报告有哮喘。6%的对照组女性出现胸痛，而在孕期各阶段出现胸痛的孕妇比例分别为1.8%、2.4%和2.4%。1.1%的对照组女性和1.2%的孕妇报告有慢性咳嗽。在诊断为GERD的情况下，孕晚期哮喘、慢性咳嗽和胸痛的比值比及95%置信区间如下：哮喘为1.56（0.58 - 4.22），慢性咳嗽为0.91（0.08 - 10.28），胸痛为2.04（0.49 - 8.46）。