Department of Obstetrics and Gynecology, Medical Faculty of Otto von Guericke University, Gerhart-Hauptmann-Str, 35, 39108, Magdeburg, Germany.
BMC Gastroenterol. 2012 Sep 24;12:131. doi: 10.1186/1471-230X-12-131.
Symptoms of gastro-esophageal reflux disease (GERD) in pregnancy are reported with a prevalence of 30-80%. The aim of this study was to assess the prevalence and severity of GERD symptoms during the course of pregnancy. Furthermore current practice in medical care for GERD during pregnancy was assessed.
We performed a prospective longitudinal cohort study on 510 pregnant women (mean age 28.12, SD 5.3). Investigations for reflux symptoms where based on the use of validated reflux-disease questionnaire (RDQ). Additional information was collected about the therapy. A group of non-pregnant women (mean age 24.56, SD 5.7) was included as controls. Frequency and severity of reflux symptoms were recorded in each trimester of pregnancy.
The prevalence of GERD symptoms in pregnant women increased from the first trimester with 26.1 to 36.1% in the second trimester and to 51.2% in the third trimester of pregnancy. The prevalence of GERD symptoms in the control group was 9.3%.Pregnant women received medication for their GERD symptoms in 12.8% during the first, 9.1% during the second and 15.7% during the third trimester. Medications used >90% antacids, 0% PPI.
GERD symptoms occur more often in pregnant women than in non-pregnant and the frequency rises in the course of pregnancy. Medical therapy is used in a minority of cases and often with no adequate symptom relief.
妊娠期间胃食管反流病（GERD）的症状报告发生率为 30-80%。本研究旨在评估妊娠过程中 GERD 症状的发生率和严重程度。此外，还评估了妊娠期间 GERD 的医疗保健现状。
我们对 510 名孕妇（平均年龄 28.12，标准差 5.3）进行了前瞻性纵向队列研究。反流症状的调查基于经过验证的反流疾病问卷（RDQ）。还收集了关于治疗的额外信息。将一组非孕妇（平均年龄 24.56，标准差 5.7）作为对照组。记录了每个妊娠 trimester 的反流症状的频率和严重程度。
孕妇 GERD 症状的发生率从第一 trimester 开始增加，从 26.1%增加到第二 trimester 的 36.1%，再增加到第三 trimester 的 51.2%。对照组中 GERD 症状的发生率为 9.3%。孕妇在第一 trimester 有 12.8%接受了 GERD 症状的药物治疗，第二 trimester 为 9.1%，第三 trimester 为 15.7%。使用的药物>90%为抗酸剂，0%为 PPI。
与非孕妇相比，孕妇更常出现 GERD 症状，且随着妊娠的进行，其发生率会增加。在少数情况下使用了药物治疗，但往往不能充分缓解症状。
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