Elzein A O M, Ali A A, Hamdan H Z, Elhassan E M, Shrif N E M A, Adam I
Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Al-Zaeim Al-azhary University, Khartoum, Sudan.
J Obstet Gynaecol. 2016;36(1):31-3. doi: 10.3109/01443615.2015.1030607.
Low birth weight (LBW) is a health concern in developing countries. Leptin and insulin-like growth factor-I (IGF-I) are factors that influence LBW. A case-control study was conducted at Medani hospital, Sudan. Cases were women who had LBW deliveries ( 2,500 g) and controls were women with normal-weight babies ( 2.500 – 4,000 g). Sociodemographic and obstetrical characteristics were gathered from both groups and leptin and IGF-I levels were measured by ELISA. Cases and controls (45 in each arm) were matched in their basic data. The median (interquartile) of maternal leptin levels [9.9 (1.9 – 21.8) vs. 16.0 (9.6 – 20.8), ng/ml; P0.001] and IGF-I [1.6 (0.7 – 20.0) vs. 6.1 (4.3 – 7.1) ng/ml ; P 0.001] were significantly lower in cases than in controls. Likewise, cord serum leptin [5.8 (2.1 – 12.6) vs. 20.0 (5.1 – 37.8) ng/ml; P0.001] and cord serum IGF-I [1.7 (1.3 – 2.0) vs. 6.9 (5.9 – 7.4) ng/ml; P0.001] levels were significantly lower in cases than in controls. Significant positive correlation was found between birth weight and cord leptin ( r0.398), maternal ( r0.795) and cord ( r0.863) IGF-I levels. Maternal and cord leptin and IGF-I levels were significantly lower in LBW babies.
低出生体重（LBW）是发展中国家的一个健康问题。瘦素和胰岛素样生长因子-I（IGF-I）是影响低出生体重的因素。在苏丹迈达尼医院进行了一项病例对照研究。病例组为分娩低出生体重儿（<2500克）的女性，对照组为分娩正常体重儿（2500 - 4000克）的女性。收集了两组的社会人口统计学和产科特征，并通过酶联免疫吸附测定法（ELISA）测量瘦素和IGF-I水平。病例组和对照组（每组45例）在基本数据上进行了匹配。病例组母亲瘦素水平的中位数（四分位数间距）[9.9（1.9 - 21.8）对16.0（9.6 - 20.8），纳克/毫升；P<0.001]和IGF-I[1.6（0.7 - 20.0）对6.1（4.3 - 7.1）纳克/毫升；P<0.001]显著低于对照组。同样，脐血血清瘦素[5.8（2.1 - 12.6）对20.0（5.1 - 37.8）纳克/毫升；P<0.001]和脐血血清IGF-I[1.7（1.3 - 2.0）对6.9（5.9 - 7.4）纳克/毫升；P<0.001]水平病例组也显著低于对照组。出生体重与脐血瘦素（r = 0.398）、母亲（r = 0.795）和脐血（r = 0.863）IGF-I水平之间存在显著正相关。低出生体重儿的母亲和脐血瘦素及IGF-I水平显著较低。
