牙釉质、牙本质和牙髓再生的组织工程方法：最新进展

Tissue Engineering Approaches for Enamel, Dentin, and Pulp Regeneration: An Update.

作者信息

Ahmed Geraldine M, Abouauf Eman A, AbuBakr Nermeen, Dörfer Christof E, El-Sayed Karim Fawzy

机构信息

Stem Cell and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Department of Endodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt.

出版信息

Stem Cells Int. 2020 Feb 25;2020:5734539. doi: 10.1155/2020/5734539. eCollection 2020.

DOI:10.1155/2020/5734539

PMID:32184832

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7060883/

Abstract

Stem/progenitor cells are undifferentiated cells characterized by their exclusive ability for self-renewal and multilineage differentiation potential. In recent years, researchers and investigations explored the prospect of employing stem/progenitor cell therapy in regenerative medicine, especially stem/progenitor cells originating from the oral tissues. In this context, the regeneration of the lost dental tissues including enamel, dentin, and the dental pulp are pivotal targets for stem/progenitor cell therapy. The present review elaborates on the different sources of stem/progenitor cells and their potential clinical applications to regenerate enamel, dentin, and the dental pulpal tissues.

摘要

干细胞/祖细胞是未分化细胞，其特征在于具有自我更新的独特能力和多谱系分化潜能。近年来，研究人员和研究探索了在再生医学中应用干细胞/祖细胞疗法的前景，尤其是源自口腔组织的干细胞/祖细胞。在这种背景下，包括牙釉质、牙本质和牙髓在内的缺失牙组织的再生是干细胞/祖细胞疗法的关键目标。本综述阐述了干细胞/祖细胞的不同来源及其在再生牙釉质、牙本质和牙髓组织方面的潜在临床应用。