Gusterson B A, Mitchell D P, Warburton M J, Carter R L
J Clin Pathol. 1983 Jun;36(6):628-31. doi: 10.1136/jcp.36.6.628.
Immunocytochemical stains for three epithelial cell markers--keratin, epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA)--have been examined on paraffin-embedded material from 14 patients with nasopharyngeal carcinoma (NPC). Tumour cells staining positively for keratin were found in all cases and for EMA in eight; two tumours contained CEA-positive cells. Seven cases of Hodgkin's disease and 24 non-Hodgkin's lymphomas were uniformly negative. Keratin is the most reliable epithelial marker for identifying NPC and excluding lymphoma. The regular finding of stainable keratin in non-keratinising and anaplastic NPC supports the view that NPC is a homogeneous group exhibiting variable degrees of squamous differentiation.
对14例鼻咽癌（NPC）患者石蜡包埋材料进行了三种上皮细胞标志物——角蛋白、上皮膜抗原（EMA）和癌胚抗原（CEA）的免疫细胞化学染色检查。所有病例中均发现肿瘤细胞对角蛋白染色呈阳性，8例对EMA染色呈阳性；2例肿瘤含有CEA阳性细胞。7例霍奇金病和24例非霍奇金淋巴瘤均为阴性。角蛋白是鉴定NPC和排除淋巴瘤最可靠的上皮标志物。在非角化和间变性NPC中经常发现可染色的角蛋白，这支持了NPC是一组表现出不同程度鳞状分化的同质肿瘤的观点。
