Shimizu Shuya, Nakazawa Takahiro, Hayashi Kazuki, Naitoh Itaru, Miyabe Katsuyuki, Kondo Hiromu, Nishi Yuji, Umemura Shuichiro, Hori Yasuki, Kato Akihisa, Morisaki Tomohito, Nanashima Atsushi, Ohara Hirotaka, Joh Takashi
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.
Intern Med. 2015;54(18):2321-6. doi: 10.2169/internalmedicine.54.4673. Epub 2015 Sep 15.
We herein report the case of a 72-year-old man who underwent photodynamic therapy (PDT) with talaporfin sodium for recurrent cholangiocarcinoma after surgical resection. Endoscopic retrograde cholangiography (ERC) showed severe stenosis with an irregular surface measuring approximately 1 cm in length from the anastomotic site, and a recurrent nodular lesion was observed at the anastomotic site of the right anterior intrahepatic bile duct on gastrointestinal endoscopy. ERC after PDT revealed a dramatic improvement in the bile duct stenosis, and the nodular lesion had disappeared. No adverse events from the PDT were detected. PDT using talaporfin sodium may be a safe alternative treatment for cholangiocarcinoma.
我们在此报告一例72岁男性患者，该患者在手术切除后因复发性胆管癌接受了用替拉泊芬钠进行的光动力疗法（PDT）。内镜逆行胆管造影（ERC）显示严重狭窄，表面不规则，从吻合口处起长度约为1厘米，并且在胃肠道内镜检查中，在右肝前叶肝内胆管的吻合口处观察到一个复发性结节性病变。PDT后的ERC显示胆管狭窄有显著改善，并且结节性病变已消失。未检测到PDT产生的不良事件。使用替拉泊芬钠的PDT可能是胆管癌的一种安全的替代治疗方法。
