J Infect Dis. 2016 Feb 15;213(4):574-8. doi: 10.1093/infdis/jiv453. Epub 2015 Sep 15.
Hemagglutination inhibition (HAI) antibody responses to anti-influenza virus hyperimmune intravenous immunoglobulin (hIVIG) were characterized. Thirty-one patients with influenza during the 2013-2014 season were randomly assigned to receive 0.25 g/kg of hIVIG (n = 16) or placebo (n = 15). For hIVIG recipients, the ratio of geometric mean titers (1 hour after infusion/before infusion) was 4.00 (95% confidence interval [CI], 2.61-6.13) for 2009 pandemic influenza A(H1N1) and 1.76 (95% CI, 1.33-2.32) for influenza A(H3N2) and influenza B. Among patients with 2009 pandemic influenza A(H1N1), ratios for hIVIG (n = 9) versus placebo (n = 8) were higher 1 hour after infusion (3.9 [95% CI, 2.3-6.7]) and sustained through day 3 (2.0 [95% CI, 1.0-4.0]). hIVIG administration significantly increases HAI titer levels among patients with influenza, supporting the need to perform a clinical outcomes study.
NCT02008578.
对流感病毒超免疫静脉注射免疫球蛋白(hIVIG)的血凝抑制(HAI)抗体反应进行了表征。2013 - 2014年流感季节的31名流感患者被随机分配接受0.25 g/kg的hIVIG(n = 16)或安慰剂(n = 15)。对于接受hIVIG的患者,2009年甲型H1N1大流行性流感的几何平均滴度比值(输注后1小时/输注前)为4.00(95%置信区间[CI],2.61 - 6.13),甲型H3N2流感和乙型流感为1.76(95% CI,1.33 - 2.32)。在2009年甲型H1N1大流行性流感患者中,接受hIVIG的患者(n = 9)与接受安慰剂的患者(n = 8)在输注后1小时的比值更高(3.9 [95% CI,2.3 - 6.7]),并持续至第3天(2.0 [95% CI,1.0 - 4.0])。给予hIVIG可显著提高流感患者的HAI滴度水平,支持开展临床结局研究的必要性。
NCT02008578。