pH对毛果芸香碱疗效的影响。
Influence of pH on the efficacy of pilocarpine.
作者信息
David R, Goldberg L, Luntz M H
出版信息
Br J Ophthalmol. 1978 May;62(5):318-9. doi: 10.1136/bjo.62.5.318.
Abstract
Pilocarpine 4% solutions at pH 4.1 and 5.8 were compared in a double-blind clinical trial on 24 eyes of patients with primary open-angle glaucoma. Each drug was used over a period of 1 week. No significant difference in the lowering of intraocular pressure was found, and the near-neutral solution of pilocarpine was found to be equally stable when compared to the acid solution over a 6-month period.
摘要
在一项针对24只原发性开角型青光眼患者眼睛的双盲临床试验中，对pH值为4.1和5.8的4%毛果芸香碱溶液进行了比较。每种药物使用1周时间。结果发现，两种溶液在降低眼压方面没有显著差异，并且在6个月的时间里，与酸性溶液相比，接近中性的毛果芸香碱溶液同样稳定。
相似文献
1
Influence of pH on the efficacy of pilocarpine.pH对毛果芸香碱疗效的影响。
Br J Ophthalmol. 1978 May;62(5):318-9. doi: 10.1136/bjo.62.5.318.
2
Double-masked cross-over comparison of Ganda 1.02 (guanethidine 1% and adrenaline 0.2% mixture) with gutt. adrenaline 1% (Simplene 1%) and with pilocarpine 1% (Sno-Pilo 1%).将甘达1.02（胍乙啶1%与肾上腺素0.2%的混合物）与1%肾上腺素滴眼液（辛普伦1%）以及1%毛果芸香碱（斯诺-匹罗1%）进行双盲交叉比较。
Br J Ophthalmol. 1981 Jan;65(1):50-2. doi: 10.1136/bjo.65.1.50.
3
[Comparative study between timolol and pilocarpine in the treatment of open-angle glaucoma (author's transl)].噻吗洛尔与毛果芸香碱治疗开角型青光眼的对比研究（作者译）
Klin Monbl Augenheilkd. 1979 Jul;175(1):91-4.
4
[Experiences in a double-blind study with different concentrations of timolol and pilocarpine (author's transl)].不同浓度噻吗洛尔与毛果芸香碱双盲研究的经验（作者译）
Klin Monbl Augenheilkd. 1980 Oct;177(4):443-50.
5
Double-blind cross-over comparison of aceclidine and pilocarpine in open-angle glaucoma.醋甲胆碱与毛果芸香碱治疗开角型青光眼的双盲交叉对照研究
Br J Ophthalmol. 1970 Aug;54(8):510-21. doi: 10.1136/bjo.54.8.510.
6
[Results of a double-blind study comparing the effects of timolol and pilocarpine in 110 patients with chronic open-angle glaucoma].
J Fr Ophtalmol. 1978 Dec;1(12):733-8.
7
[Experiences with timolol in treatment of glaucoma (author's transl)].
Klin Monbl Augenheilkd. 1978 Aug;173(2):202-7.
8
[The effect of low concentrations of pilocarpine with phenylephrine on intraocular pressure in glaucoma (author's transl)].低浓度毛果芸香碱与去氧肾上腺素对青光眼眼压的影响（作者译）
Klin Monbl Augenheilkd. 1978 Oct;173(4):533-6.
9
10
Effects on intraocular pressure and pupil size in glaucomatous beagles after topical pilocarpine instilled with standard (pH 5) and buffer-tip (pH 7) droptainers.
J Ocul Pharmacol Ther. 1997 Apr;13(2):95-104. doi: 10.1089/jop.1997.13.95.
引用本文的文献
1
Safety and Efficacy of AGN-190584 in Individuals With Presbyopia: The GEMINI 1 Phase 3 Randomized Clinical Trial.AGN-190584 治疗老视患者的安全性和疗效：GEMINI 1 期 3 项随机临床试验。
JAMA Ophthalmol. 2022 Apr 1;140(4):363-371. doi: 10.1001/jamaophthalmol.2022.0059.
本文引用的文献
1
Influence of pH on the effect of pilocarpine on aqueous dynamics.pH对毛果芸香碱对房水动力学影响的作用
Br J Ophthalmol. 1968 Aug;52(8):607-11. doi: 10.1136/bjo.52.8.607.
Zotero 插件