Leydhecker W, Krieglstein G K
Klin Monbl Augenheilkd. 1978 Oct;173(4):533-6.
Orientating preliminary trials showed that the reducing action of pilocarpine on intraocular pressure is considerably enhanced by adding the alpha-receptor stimulant phenylephrine. Pilocarpine eyedrops 1% and pilocarpine drops 1% with phenylephrine 0.25% were compared in two double-blind crossover studies. Pressure reduction was more pronounced after administering the combination, the width of the pupil remaining unchanged. Attention is drawn to the advantages of pressure reduction without narrowing of the pupils in the treatment of all types of open-angle glaucoma. Miosis is of therapeutical advantage only in angle-closure glaucoma; hence, for reasons of safety, administration of phenylephrine should be avoided.
初步的定向试验表明，加入α受体兴奋剂去氧肾上腺素可显著增强毛果芸香碱对眼压的降低作用。在两项双盲交叉研究中，对1%毛果芸香碱滴眼液和含0.25%去氧肾上腺素的1%毛果芸香碱滴眼液进行了比较。联合用药后降压效果更明显，瞳孔宽度保持不变。需注意在治疗各类开角型青光眼时，不缩瞳降压的优势。瞳孔缩小仅在闭角型青光眼中具有治疗优势；因此，出于安全考虑，应避免使用去氧肾上腺素。
