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1
Double-masked cross-over comparison of Ganda 1.02 (guanethidine 1% and adrenaline 0.2% mixture) with gutt. adrenaline 1% (Simplene 1%) and with pilocarpine 1% (Sno-Pilo 1%).将甘达1.02（胍乙啶1%与肾上腺素0.2%的混合物）与1%肾上腺素滴眼液（辛普伦1%）以及1%毛果芸香碱（斯诺-匹罗1%）进行双盲交叉比较。
Br J Ophthalmol. 1981 Jan;65(1):50-2. doi: 10.1136/bjo.65.1.50.
2
Evaluation of a 5% guanethidine and 0.5% adrenaline mixture (Ganda 5.05) and of a 3% guanethidine and 0.5% adrenaline mixture (Ganda 3.05) in the treatment of open-angle glaucoma.评估5%胍乙啶与0.5%肾上腺素混合剂（Ganda 5.05）和3%胍乙啶与0.5%肾上腺素混合剂（Ganda 3.05）治疗开角型青光眼的效果。
Br J Ophthalmol. 1979 Jan;63(1):52-5. doi: 10.1136/bjo.63.1.52.
3
The additional pressure-lowering effect in patients with glaucoma of pilocarpine 2 per cent, adrenaline 1 per cent, or guanethidine 3 per cent with adrenaline 0.5 per cent and timolol 0.25 per cent: a double-blind cross-over study.
Trans Ophthalmol Soc U K (1962). 1983;103 ( Pt 6):588-92.
4
Adrenaline 1% combined with guanethidine 1% versus adrenaline 1%: a randomised prospective double-blind cross-over study.
Br J Ophthalmol. 1982 Apr;66(4):247-9. doi: 10.1136/bjo.66.4.247.
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Acta Ophthalmol (Copenh). 1978 Apr;56(2):191-200. doi: 10.1111/j.1755-3768.1978.tb01345.x.
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Control of glaucoma by reduced dosage guanethidine-adrenaline formulation.通过降低胍乙啶-肾上腺素制剂剂量来控制青光眼。
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Therapeutic trial of the combination in an eye lotion of adrenaline (0.5 or 1%) and guanethidine (3 or 5%) in cases of open-angle glaucoma.
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引用本文的文献

1
Adrenaline 1% combined with guanethidine 1% versus adrenaline 1%: a randomised prospective double-blind cross-over study.
Br J Ophthalmol. 1982 Apr;66(4):247-9. doi: 10.1136/bjo.66.4.247.
2
Low-dose combined guanethedine 1% and adrenaline 0.5% in the treatment of chronic simple glaucoma: a prospective study.低剂量1%胍乙啶与0.5%肾上腺素联合治疗慢性单纯性青光眼：一项前瞻性研究。
Br J Ophthalmol. 1981 Aug;65(8):533-5. doi: 10.1136/bjo.65.8.533.

本文引用的文献

1
Low centration guanethidine and adrenaline therapy of glaucoma. A preliminary report.
Trans Ophthalmol Soc U K (1962). 1976 Apr;96(1):179-83.
2
The combination of guanethidine 3% and adrenaline 0.5% in 1 eyedrop (GA) in glaucoma treatment.在青光眼治疗中，1滴眼剂中含3%胍乙啶和0.5%肾上腺素的组合（GA）
Br J Ophthalmol. 1979 Jan;63(1):56-62. doi: 10.1136/bjo.63.1.56.
3
Evaluation of a 5% guanethidine and 0.5% adrenaline mixture (Ganda 5.05) and of a 3% guanethidine and 0.5% adrenaline mixture (Ganda 3.05) in the treatment of open-angle glaucoma.评估5%胍乙啶与0.5%肾上腺素混合剂（Ganda 5.05）和3%胍乙啶与0.5%肾上腺素混合剂（Ganda 3.05）治疗开角型青光眼的效果。
Br J Ophthalmol. 1979 Jan;63(1):52-5. doi: 10.1136/bjo.63.1.52.
4
Low dosage combined adrenaline-guanethidine formulations in the management of chronic simple glaucoma.
Trans Ophthalmol Soc U K (1962). 1977 Apr;97(1):192-5.
5
A double-blind short-term trial of guanethidine 3% and adrenaline 0.5% combined in one eye drop.一项关于将3%胍乙啶和0.5%肾上腺素混合于一种滴眼液中的双盲短期试验。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1977 Jul 8;203(1):73-80. doi: 10.1007/BF00410049.

将甘达1.02（胍乙啶1%与肾上腺素0.2%的混合物）与1%肾上腺素滴眼液（辛普伦1%）以及1%毛果芸香碱（斯诺-匹罗1%）进行双盲交叉比较。

Double-masked cross-over comparison of Ganda 1.02 (guanethidine 1% and adrenaline 0.2% mixture) with gutt. adrenaline 1% (Simplene 1%) and with pilocarpine 1% (Sno-Pilo 1%).

作者信息

Romano J H, Nagasubramanian S, Poinoosawmy D

出版信息

Br J Ophthalmol. 1981 Jan;65(1):50-2. doi: 10.1136/bjo.65.1.50.

DOI:10.1136/bjo.65.1.50
PMID:7004478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1039412/
Abstract

A trial of the efficacy of low-concentration nonmiotic therapy was carried out, the aim being to minimise the side effects produced by 1% adrenaline or pilocarpine. A total of 77 eyes with open-angle glaucoma were studied in both parts of the trial. Thirty-nine eyes had a base-line pressure of over 28 mmHg and 28 eyes a pressure of 30 mmHg or over. In the comparison between Ganda 1.02 and adrenaline 1% (Simplene) the mean lowering of intraocular pressure was 8.6 mmHg with Ganda and 7.69 mmHg with Simplene. In the comparison between Ganda 1.02 and pilocarpine 1% (Sno-Pilo) the mean decrease was 6.34 mmHg with Ganda and 6.13 mmHg with Sno-Pilo. The resulting falls in intraocular pressure were highly significant statistically, but the differences between the effects of the 3 drugs were not significant. No significant side effects were reported with Ganda 1.02, and in particular no ptosis or superficial punctate staining of the cornea was noted.

摘要

进行了一项低浓度非缩瞳疗法疗效的试验，目的是尽量减少1%肾上腺素或毛果芸香碱产生的副作用。试验的两个部分共研究了77只开角型青光眼眼。39只眼基线眼压超过28 mmHg，28只眼眼压为30 mmHg或更高。在甘达1.02与1%肾上腺素（Simplene）的比较中，甘达使眼压平均降低8.6 mmHg，Simplene使眼压平均降低7.69 mmHg。在甘达1.02与1%毛果芸香碱（Sno-Pilo）的比较中，甘达使眼压平均降低6.34 mmHg，Sno-Pilo使眼压平均降低6.13 mmHg。眼压下降在统计学上具有高度显著性，但这三种药物效果之间的差异不显著。未报告甘达1.02有显著副作用，尤其未发现上睑下垂或角膜浅层点状染色。