Contu Laura, Hawkes Cheryl A
School of Life, Health and Chemical Sciences, Science, Technology, Engineering and Mathematics (STEM) Faculty, Open University, Walton Hall, Milton Keynes MK7 6AA, UK.
Int J Mol Sci. 2017 May 19;18(5):1093. doi: 10.3390/ijms18051093.
Globally, more than 20% of women of reproductive age are currently estimated to be obese. Children born to obese mothers are at higher risk of developing obesity, coronary heart disease, diabetes, stroke, and asthma in adulthood. Increasing clinical and experimental evidence suggests that maternal obesity also affects the health and function of the offspring brain across the lifespan. This review summarizes the current findings from human and animal studies that detail the impact of maternal obesity on aspects of learning, memory, motivation, affective disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, and neurodegeneration in the offspring. Epigenetic mechanisms that may contribute to this mother-child interaction are also discussed.
据估计，全球目前超过20%的育龄妇女肥胖。肥胖母亲所生的孩子在成年后患肥胖症、冠心病、糖尿病、中风和哮喘的风险更高。越来越多的临床和实验证据表明，母亲肥胖还会在整个生命周期中影响后代大脑的健康和功能。这篇综述总结了来自人类和动物研究的当前发现，这些发现详细阐述了母亲肥胖对后代学习、记忆、动机、情感障碍、注意力缺陷多动障碍、自闭症谱系障碍和神经退行性变等方面的影响。文中还讨论了可能导致这种母婴相互作用的表观遗传机制。
