Liao C D, Lin C Y, Chen W P, Hwang B T, Tasi S T
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1989 May-Jun;30(3):191-5.
A female newborn of SLE mother developed transient typical discoid-like lupus skin lesions over her face soon after birth and had severe relapse with generalized spreading following an episode of upper respiratory tract infection at 50 days of age. Blood picture showed anemia, transient thrombocytopenia and high ESR. Cardiac echo disclosed small ASD with minimal TR. Both EKG and 24 hrs EKG monitor presented normal findings. Serological studies at the early relapse stage of this disease showed increased serum ANA, IgA and IgM level with normal IgG and decrease of C3 and C4. Both Ro(SSA) and La(SSB) antibody systems were positive in mother but only positive for La(SSB) antibody system in this baby. The alpha-anticardiolipin antibody was negative. We suggest that the Ro(SSA) and/or La(SSB) antibody systems may play a role in the pathogenesis of neonatal lupus erythematosus.
一位患有系统性红斑狼疮（SLE）的母亲所生的女婴，出生后不久面部即出现短暂的典型盘状狼疮样皮肤损害，50日龄时因上呼吸道感染发作而出现严重复发，皮疹泛发全身。血常规显示贫血、短暂性血小板减少和血沉增快。心脏超声显示小型房间隔缺损伴轻度三尖瓣反流。心电图及24小时动态心电图监测均显示正常结果。该病早期复发阶段的血清学研究显示，血清抗核抗体（ANA）、免疫球蛋白A（IgA）和免疫球蛋白M（IgM）水平升高，免疫球蛋白G（IgG）正常，补体C3和C4降低。母亲的Ro（SSA）和La（SSB）抗体系统均为阳性，但该婴儿仅La（SSB）抗体系统呈阳性。抗心磷脂抗体为阴性。我们认为，Ro（SSA）和/或La（SSB）抗体系统可能在新生儿红斑狼疮的发病机制中起作用。
