新型氟喹诺酮酮内酯司帕沙星（CEM-101）对大量临床淋病奈瑟菌分离株和国际参考菌株的体外活性，包括那些具有高水平抗菌耐药性的菌株：淋病的潜在治疗选择？
In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea?
机构信息
WHO Collaborating Centre for Gonorrhoea and other STIs, National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
出版信息
Antimicrob Agents Chemother. 2012 May;56(5):2739-42. doi: 10.1128/AAC.00036-12. Epub 2012 Feb 21.
Abstract
Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the first fluoroketolide, solithromycin. Clinical Neisseria gonorrhoeae isolates and reference strains (n = 246), including the two extensively drug-resistant strains H041 and F89 and additional isolates with clinical cephalosporin resistance and multidrug resistance, were examined. The activity of solithromycin was mainly superior to that of other antimicrobials (n = 10) currently or previously recommended for gonorrhea treatment. Solithromycin might be an effective treatment option for gonorrhea.
摘要
淋病可能变得无法治疗，因此需要新的治疗方案。我们研究了首个氟喹诺酮酮内酯类药物——索利霉素的体外活性。检测了临床淋病奈瑟菌分离株和参考株（n = 246），包括两种广泛耐药菌株 H041 和 F89 以及其他具有临床头孢菌素耐药性和多药耐药性的分离株。索利霉素的活性主要优于目前或以前推荐用于淋病治疗的其他十种（n = 10）抗菌药物。索利霉素可能是淋病的一种有效治疗选择。
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