中国农村老年人群的硒水平与血脂异常
Selenium Level and Dyslipidemia in Rural Elderly Chinese.
作者信息
Su Liqin, Gao Sujuan, Unverzagt Frederick W, Cheng Yibin, Hake Ann M, Xin Pengju, Chen Chen, Liu Jingyi, Ma Feng, Bian Jianchao, Li Ping, Jin Yinlong
机构信息
Department of Environmental Impact Assessment, Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing, China.
Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.
出版信息
PLoS One. 2015 Sep 18;10(9):e0136706. doi: 10.1371/journal.pone.0136706. eCollection 2015.
OBJECTIVE
Higher selenium level has been hypothesized to have the potential to reduce the risk of cardiovascular diseases including dyslipidemia. However, results from previous studies are inconsistent. This study aims to determine the association between selenium level and dyslipidemia in elderly Chinese with relatively low selenium status.
METHODS
A cross-sectional study of 1859 participants aged 65 or older from four rural counties in China was conducted. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDLC) and low-density lipoprotein-cholesterol (LDLC), nail selenium concentration and APOE genotype were measured in all subjects. The four types of dyslipidemia were defined as >5.17 mmol/L for High-TC, >1.69 mmol/L for High-TG, >3.36 mmol/L for High-LDLC, and <1.04 mmol/L for Low-HDLC according to Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. Logistic models adjusting for age, gender, APOE genotype, body mass index, alcohol consumption, smoking, physical activity, medication use for cardiovascular diseases were used to examine the relationship between selenium levels and the risk of dyslipidemia.
RESULTS
Mean nail selenium concentration was 0.465 μg/gin this sample. Rates for High-TC, High-LDLC, High-TG, Low-HDLC were 18.13%, 13.23%, 12.21% and 32.76% respectively. Results from logistic models indicated that higher selenium levels were significantly associated with higher risk of High-TC, High-LDLC and lower risk of Low-HDLC adjusting for covariates (p < 0.0001). Compared with the lowest selenium quartile group, participants in selenium quartile groups 2, 3 and 4 had significantly higher rates of High-TC, High-LDLC, High-TG, and lower rate of Low-HDLC adjusting for covariates. No significant association was observed between selenium level and the risk of High-TG. APOEε4 carriers had higher rates of High-TC and High-LDLC. There was no interaction between selenium level and APOE with the rates of dyslipidemia.
CONCLUSIONS
Our results suggest long-term selenium exposure level may be associated with the risk of dyslipidemia in elderly population. Future studies are needed to examine the underlying mechanism of the association.
目的
有假设认为较高的硒水平有可能降低包括血脂异常在内的心血管疾病风险。然而，以往研究结果并不一致。本研究旨在确定在中国老年人群中，硒水平与血脂异常之间的关联，这些人群的硒水平相对较低。
方法
对来自中国四个乡村县的1859名65岁及以上参与者进行了一项横断面研究。测量了所有受试者的血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDLC）和低密度脂蛋白胆固醇（LDLC）、指甲硒浓度和APOE基因型。根据《中国成人血脂异常防治指南》，四种血脂异常类型定义为：高TC>5.17 mmol/L，高TG>1.69 mmol/L，高LDLC>3.36 mmol/L，低HDLC<1.04 mmol/L。采用调整年龄、性别、APOE基因型、体重指数、饮酒、吸烟、体力活动、心血管疾病用药情况的逻辑模型，研究硒水平与血脂异常风险之间的关系。
结果
本样本中指甲硒浓度的平均值为0.465μg/g。高TC、高LDLC、高TG、低HDLC的发生率分别为18.13%、13.23%、12.21%和32.76%。逻辑模型结果表明，调整协变量后，较高的硒水平与高TC、高LDLC的较高风险以及低HDLC的较低风险显著相关（p<0.0001）。与最低硒四分位数组相比，调整协变量后，硒四分位数组2、3和4中的参与者高TC、高LDLC、高TG的发生率显著更高，低HDLC的发生率更低。未观察到硒水平与高TG风险之间存在显著关联。APOEε4携带者高TC和高LDLC的发生率更高。硒水平与APOE之间不存在血脂异常发生率的交互作用。
结论
我们的结果表明，长期硒暴露水平可能与老年人群的血脂异常风险相关。未来需要进一步研究来探讨这种关联的潜在机制。
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