Flório J C, Sakate M, Palermo-Neto J
Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1989;22(10):1291-3.
Acute oral administration of the pesticide amitraz at the doses of 60 and 100 mg/kg (N = 10 per group) significantly decreased the rearing frequency of rats observed in an open field to 8 +/- 8 and 5 +/- 5, respectively, when compared to 28 +/- 5 for control rats treated with vehicle only. The same doses of amitraz (N = 10 per group) increased duration of immobility to 80 +/- 50 and 113 +/- 64 s, respectively, when compared to 113 +/- 64 s for the controls. Acute oral administration of amitraz (20, 60 or 100 mg/kg, N = 10 per group) significantly increased the convulsive threshold dose of rats for strychnine, picrotoxin and pentylenetetrazole. Amitraz administered ip to mice at the doses of 20, 60 and 100 mg/kg (N = 10 per group) significantly increased sleeping time in a dose-dependent manner to 96 +/- 26, 120 +/- 29 and 198 +/- 58 min, respectively, when compared to 45 +/- 15 min for control mice treated with vehicle only. These results indicate that amitraz produces a depressant effect on the central nervous system.
急性口服剂量为60和100毫克/千克的农药双甲脒（每组N = 10），与仅用赋形剂处理的对照大鼠（28±5）相比，显著降低了在旷场试验中观察到的大鼠竖毛频率，分别降至8±8和5±5。相同剂量的双甲脒（每组N = 10）使不动时间分别增加到80±50和113±64秒，而对照组为113±64秒。急性口服双甲脒（20、60或100毫克/千克，每组N = 10）显著提高了大鼠对士的宁、印防己毒素和戊四氮的惊厥阈值剂量。以20、60和100毫克/千克的剂量腹腔注射双甲脒给小鼠（每组N = 10），与仅用赋形剂处理的对照小鼠（45±15分钟）相比，显著以剂量依赖的方式增加睡眠时间，分别达到96±26、120±29和198±58分钟。这些结果表明双甲脒对中枢神经系统产生抑制作用。
