The potential use of probiotics in controlling enteric infections has generated tremendous interest in the last decade. The protective efficacy of seven oral doses of two newly isolated Egyptian probiotic strains; Lactobacillus acidophilus P110 (L. acidophilus) and Lactobacillus plantarum P164 (L. plantarum) versus Lactobacillus casei ATCC 7469 (L. casei) - against experimental intestinal trichinellosis - was assessed via parasitological, immunological and histopathological parameters, after verifying their in vivo safety and intestinal colonization. Parasitologically, the highest adult count reduction was observed in L. plantarum-fed infected sub-subgroup (56.98, 65.42 and 69.02%) - on the 5th, 12th and 17th days post infection (P.I.), respectively. Lesser percentage reductions were recorded in both the L. casei-fed infected sub-subgroup (36.19, 23.68 and 31.58%) and L. acidophilus-fed infected sub-subgroup (36.50, 11.8 and 7.61%) at the same intervals. On the 28th day post challenge, the highest larval count reduction was in L. plantarum-fed infected sub-subgroup (87.92%). While lower percentage yet still significant were observed in the L. casei-fed infected (74.88%) and L. acidophilus-fed infected sub-subgroups (60.98%). Immunologically, serum IFN-γ levels in the probiotic-fed non infected sub-subgroups were higher than those in the probiotic-fed infected sub-subgroups. Both showed higher levels of IFN-γ than the non probiotic-fed sub-subgroups. Histopathologically, intestinal sections of the probiotic-fed infected sub-subgroups showed amelioration of the inflammation and damage resulting from Trichinella spiralis (T. spiralis) infection. Results indicate that, through mechanical and immunological mechanisms, L. plantarum showed parasitological and histopathological protective superiority with respect to both L. casei and L. acidophilus against murine T. spiralis infection.