Vitale Roxana G
Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina.
Unidad de Parasitología, Sector Micología, Hospital J. M. Ramos Mejía, Buenos Aires, Argentina.
J Fungi (Basel). 2021 Sep 6;7(9):731. doi: 10.3390/jof7090731.
infections are varied and, depending on the immune status of the patient, a life-threatening form may develop. is the most prevalent species isolated, however, a significant shift towards other species has been noted. Monotherapy is frequently indicated, but the patient's evolution is not always favorable. Drug combinations are a suitable option in specific situations. The aim of this review is to address this problem and to discuss the role of drug combinations in difficult to treat infections. A search for eligible studies in PubMed and Google Scholar databases was performed. An analysis of the data was carried out to define in which cases a combination therapy is the most appropriate. Combination therapy may be used for refractory candidiasis, endocarditis, meningitis, eye infections and osteomyelitis, among others. The role of the drug combination would be to increase efficacy, reduce toxicity and improve the prognosis of the patient in infections that are difficult to treat. More clinical studies and reporting of cases in which drug combinations are used are needed in order to have more data that support the use of this therapeutic strategy.
感染多种多样，根据患者的免疫状态，可能会发展成危及生命的形式。 是分离出的最常见菌种，然而，已注意到向其他菌种的显著转变。通常采用单一疗法，但患者的病情发展并非总是良好。在特定情况下，联合用药是一种合适的选择。本综述的目的是解决这一问题，并讨论联合用药在难治性 感染中的作用。在PubMed和谷歌学术数据库中搜索符合条件的研究。对数据进行分析，以确定在哪些情况下联合治疗是最合适的。联合治疗可用于难治性念珠菌病、心内膜炎、脑膜炎、眼部感染和骨髓炎等。联合用药的作用是提高疗效、降低毒性并改善难治性感染患者的预后。为了获得更多支持这种治疗策略的数据，需要更多使用联合用药的临床研究和病例报告。
