McDougall P N, Fleming P J, Speller D C, Daish P, Speidel B D
Arch Dis Child. 1982 Nov;57(11):884-6. doi: 10.1136/adc.57.11.884.
Two extremely preterm infants undergoing intensive care who developed systemic candidiasis are reported. Each was treated initially with intravenous miconazole. One child initially responded, but relapsed after the miconazole was stopped. The second child showed evidence of progression of the disease during treatment. Both infants responded to a combined course of amphotericin B and 5-fluorocytosine. We consider that miconazole is not the drug of first choice in the treatment of neonatal systemic candidiasis.
报道了两名接受重症监护的极早产儿发生全身性念珠菌病的病例。两名患儿最初均接受静脉注射咪康唑治疗。一名患儿最初有反应，但在停用咪康唑后复发。第二名患儿在治疗期间出现病情进展的迹象。两名婴儿对两性霉素B和5-氟胞嘧啶联合疗程均有反应。我们认为咪康唑不是治疗新生儿全身性念珠菌病的首选药物。
