Rui Ke, Zhang Zhijiang, Tian Jie, Lin Xiang, Wang Xiaohui, Ma Jie, Tang Xinyi, Xu Huaxi, Lu Liwei, Wang Shengjun
Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Institute of Laboratory Medicine and Department of Histology, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University, Zhenjiang, China.
Cell Mol Immunol. 2016 May;13(3):401-8. doi: 10.1038/cmi.2015.82. Epub 2015 Sep 21.
Recent studies have identified olfactory ecto-mesenchymal stem cells (OE-MSCs) as a new type of resident stem cell in the olfactory lamina propria. However, it remains unclear whether OE-MSCs possess any immunoregulatory functions. In this study, we found that mouse OE-MSCs expressed higher transforming growth factor-beta and interleukin-10 levels than bone marrow-derived MSCs. In culture, OE-MSCs exerted their immunosuppressive capacity via directly suppressing effector T-cell proliferation and increasing regulatory T (Treg) cell expansion. In mice with collagen-induced arthritis, adoptive transfer of OE-MSCs markedly suppressed arthritis onset and disease severity, which was accompanied by increased Treg cells and reduced Th1/Th17 cell responses in vivo. Taken together, our findings identified a novel function of OE-MSCs in regulating T-cell responses, indicating that OE-MSCs may represent a new cell therapy for the treatment of rheumatoid arthritis and other autoimmune diseases.
最近的研究已将嗅觉外间充质干细胞（OE-MSCs）鉴定为嗅黏膜固有层中的一种新型驻留干细胞。然而，OE-MSCs是否具有任何免疫调节功能仍不清楚。在本研究中，我们发现小鼠OE-MSCs表达的转化生长因子-β和白细胞介素-10水平高于骨髓来源的间充质干细胞。在培养过程中，OE-MSCs通过直接抑制效应T细胞增殖和增加调节性T（Treg）细胞扩增发挥其免疫抑制能力。在胶原诱导的关节炎小鼠中，OE-MSCs的过继转移显著抑制了关节炎的发作和疾病严重程度，这伴随着体内Treg细胞增加和Th1/Th17细胞反应减少。综上所述，我们的研究结果确定了OE-MSCs在调节T细胞反应中的新功能，表明OE-MSCs可能代表一种用于治疗类风湿性关节炎和其他自身免疫性疾病的新细胞疗法。
