Center of Reproduction, Development & Aging, and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, China.
Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau, China.
Int J Biol Sci. 2022 Jul 15;18(12):4795-4808. doi: 10.7150/ijbs.73485. eCollection 2022.
COVID-19 is hopefully approaching its end in many countries as herd immunity develops and weaker strains of SARS-CoV-2 dominate. However, a new concern occurs over the long-term effects of COVID-19, collectively called "Long COVID", as some symptoms of the nervous system last even after patients recover from COVID-19. This review focuses on studies of anosmia, , impairment of smell, which is the most common sensory defect during the disease course and is caused by olfactory dysfunctions. It remains mysterious how the olfactory functions are affected since the virus can't invade olfactory receptor neurons. We describe several leading hypotheses about the mystery in hope to provide insights into the pathophysiology and treatment strategies for anosmia.
随着群体免疫的形成和 SARS-CoV-2 弱毒株的主导，许多国家的 COVID-19 疫情有望结束。然而，人们对 COVID-19 的长期影响产生了新的担忧，统称为“长新冠”，因为一些神经系统症状即使在患者从 COVID-19 中康复后仍会持续存在。这篇综述重点关注了嗅觉障碍的研究，嗅觉障碍是疾病过程中最常见的感觉缺陷，是由嗅觉功能障碍引起的。由于病毒无法侵入嗅觉受体神经元，嗅觉功能如何受到影响仍然是个谜。我们描述了几个关于这一谜团的主要假设，希望能为嗅觉障碍的病理生理学和治疗策略提供一些见解。
